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1. Mor N, Lutsky I, Levy L: Response in distant lymph nodes of mice to infection in the hind footpad with Mycobacterium marinum. Infect Immun; 1980 Apr;28(1):225-9
MedlinePlus Health Information. consumer health - Mycobacterial Infections.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Response in distant lymph nodes of mice to infection in the hind footpad with Mycobacterium marinum.
  • In an attempt to demonstrate the importance of the popliteal lymph node in limiting the progress of infection with Mycobacterium marinum in the hind footpads of C57BL mice, such infections were studied in mice subjected to popliteal or popliteal and inguinal adenectomies.
  • In the absence of the popliteal node, the footpad infection was only slightly enhanced compared with infections of sham-operated control mice; the inguinal node was found to be greatly enlarged and appeared to have substituted for the absent popliteal node.
  • In additional experiments, mice subjected to adenectomy only on one side and injected in that hind footpad with phytohemagglutinin or India ink demonstrated hypertrophy or deposition of carbon particles in the more distant node only on the side of the injection.
  • Thus, there appear to be rather direct functional connections among popliteal, inguinal, and axillary nodes that do not depend on blood circulation.
  • [MeSH-minor] Animals. Hindlimb. Lymph Node Excision. Lymphocyte Activation. Lymphocytes / immunology. Macrophages / immunology. Mice. Mice, Inbred C57BL. Nontuberculous Mycobacteria / growth & development. Organ Size

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  • (PMID = 7380564.001).
  • [ISSN] 0019-9567
  • [Journal-full-title] Infection and immunity
  • [ISO-abbreviation] Infect. Immun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Other-IDs] NLM/ PMC550916
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2. Lok J, Zhao S, Leung W, Seo JH, Navaratna D, Wang X, Whalen MJ, Lo EH: Neuregulin-1 effects on endothelial and blood-brain-barrier permeability after experimental injury. Transl Stroke Res; 2012 Jul;3 Suppl 1:S119-24

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  • Therefore, blood-brain-barrier integrity is an important potential therapeutic target in the treatment of the acute phase of brain trauma.
  • For in-vivo studies, C57Bl mice were subjected to controlled cortical impact (CCI) under anesthesia, and BBB permeability was assessed by measuring the amount of Evans blue dye extravasation at 2h.

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  • (PMID = 22773936.001).
  • [ISSN] 1868-601X
  • [Journal-full-title] Translational stroke research
  • [ISO-abbreviation] Transl Stroke Res
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / K08 NS057339; United States / NINDS NIH HHS / NS / R01 NS053560; United States / NINDS NIH HHS / NS / R01 NS076694
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS376408; NLM/ PMC3389802
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3. Peng F, Lutsenko S, Sun X, Muzik O: Positron emission tomography of copper metabolism in the Atp7b-/- knock-out mouse model of Wilson's disease. Mol Imaging Biol; 2012 Feb;14(1):70-8
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  • [Title] Positron emission tomography of copper metabolism in the Atp7b-/- knock-out mouse model of Wilson's disease.
  • PROCEDURES: Atp7b⁻/⁻ mice, a mouse model of human WD, were injected with ⁶⁴CuCl₂ intravenously and subjected to PET scanning using a hybrid PET-CT (computerized tomography) scanner, with the wild-type C57BL mice as a normal control.
  • RESULTS: Dynamic PET analysis revealed increased accumulation and markedly reduced clearance of ⁶⁴Cu from the liver of the Atp7b⁻/⁻ mice, compared to hepatic uptake and clearance of ⁶⁴Cu in the wild-type C57BL mice.
  • Kinetics of copper clearance and retention was also altered for kidneys, heart, and lungs in the Atp7b/⁻ mice.
  • Based on biodistribution of ⁶⁴Cu in wild-type C57BL mice, radiation dosimetry estimates of ⁶⁴Cu in normal human subjects were obtained, showing an effective dose (ED) of 32.2 μ (micro)Sv/MBq (weighted dose over 22 organs) and the small intestine as the critical organ for radiation dose (61 μGy/MBq for males and 69 μGy/MBq for females).
  • Radiation dosimetry estimates for the patients with WD, based on biodistribution of ⁶⁴Cu in the Atp7b⁻/⁻ mice, showed a similar ED of 32.8 μ (micro)Sv/MBq (p = 0.53), with the liver as the critical organ for radiation dose (120 μSv/MBq for male and 161 μSv/MBq for female).
  • CONCLUSIONS: Quantitative PET analysis demonstrates abnormal copper metabolism in the mouse model of WD with improved time-resolution.
  • Human radiation dosimetry estimates obtained in this preclinical study encourage direct radiation dosimetry of ⁶⁴CuCl₂ in human subjects.

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  • Hazardous Substances Data Bank. COPPER, ELEMENTAL .
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  • (PMID = 21327972.001).
  • [ISSN] 1860-2002
  • [Journal-full-title] Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
  • [ISO-abbreviation] Mol Imaging Biol
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R56DK084510; United States / NIBIB NIH HHS / EB / R21EB005331-01A2; United States / NCI NIH HHS / CA / R24 CA086307; United States / NIBIB NIH HHS / EB / R21 EB005331; United States / NIBIB NIH HHS / EB / R21 EB005331-01A2; United States / NIBIB NIH HHS / EB / EB005331-01A2; United States / NCI NIH HHS / CA / R24CA86307; United States / NIDDK NIH HHS / DK / R56 DK084510
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cation Transport Proteins; 0 / Copper Radioisotopes; 7447-39-4 / cupric chloride; 789U1901C5 / Copper; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.3.4 / Atp7a protein, mouse
  • [Other-IDs] NLM/ NIHMS291248; NLM/ PMC3157550
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4. Burdon D, Tiedje T, Pfeffer K, Vollmer E, Zabel P: The role of tumor necrosis factor in the development of multiple organ failure in a murine model. Crit Care Med; 2000 Jun;28(6):1962-7
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  • OBJECTIVE: To elucidate the role of tumor necrosis factor (TNF) in the development of multiple organ dysfunction syndrome (MODS) after zymosan-induced peritonitis in mice.
  • DESIGN: Prospective controlled laboratory study on zymosan-induced generalized inflammation in mice.
  • Over < or =28 days, a single intraperitoneal administration of zymosan induced a three-phase illness in C57BL mice, rendering them very ill with MODS-like symptoms from day 7 onward.
  • Additionally, the same experiment was performed on C57BL/6 TNF-Rc-p55 knockout mice to elucidate the role of TNF and its receptor p55.
  • SUBJECTS: Inbred C57BL mice and C57BL p55-/- mice received a single sterile intraperitoneal injection of zymosan suspended in paraffin oil (0.75 mg/g of body weight).
  • The C57BL mice developed MODS with typical symptoms and histopathologic results correlating with excessive TNF-alpha mRNA expression from day 7 onward.
  • In contrast, no disease, histopathologic changes, nor TNF-alpha mRNA expression in liver or lung was found within the TNF-Rc-p55-/- mice.
  • [MeSH-minor] Animals. Bronchoalveolar Lavage Fluid. Mice. Mice, Inbred C57BL. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction. Zymosan

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  • [CommentIn] Crit Care Med. 2000 Jun;28(6):2158-9 [10890694.001]
  • (PMID = 10890648.001).
  • [ISSN] 0090-3493
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha; 9010-72-4 / Zymosan
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5. Hong GU, Lim JY, Kim NG, Shin JH, Ro JY: IgE and IgA produced by OX40-OX40L or CD40-CD40L interaction in B cells-mast cells re-activate FcεRI or FcαRI on mast cells in mouse allergic asthma. Eur J Pharmacol; 2015 May 5;754:199-210
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] IgE and IgA produced by OX40-OX40L or CD40-CD40L interaction in B cells-mast cells re-activate FcεRI or FcαRI on mast cells in mouse allergic asthma.
  • C57BL mice were sensitized and subjected to OVA challenge to induce asthma.
  • Anti-CD40 plus anti-OX40L Abs synergistically reduced IgE and IgA production, and mediators (histamine, LTs and cytokines) released in mast cells, and additively reduced other responses, such as, numbers of mast cells, the expression of markers (tryptase, mMCP5, B220 and CD19), surface molecules (CD40, CD40L, OX40 and OX40L), FcεRI or FcαRI and the co-localization of BMMCs and B cells, and IgE- or IgA-producing cells, as compared with individual blocking Ab treatment which reducedresponses in BAL cells or lung tissues of OVA-challenged mice or in co-culture of B and mast cells.
  • [MeSH-minor] Animals. Cell Movement / immunology. Coculture Techniques. Cytokines / metabolism. Female. Histamine / metabolism. Lung / immunology. Mice

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  • [Copyright] Copyright © 2015 Elsevier B.V. All rights reserved.
  • (PMID = 25704619.001).
  • [ISSN] 1879-0712
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD40; 0 / Antigens, Differentiation; 0 / Cytokines; 0 / Fc(alpha) receptor; 0 / Immunoglobulin A; 0 / OX40 Ligand; 0 / OX40Ig; 0 / Receptors, Fc; 0 / Receptors, IgE; 147205-72-9 / CD40 Ligand; 37341-29-0 / Immunoglobulin E; 820484N8I3 / Histamine
  • [Keywords] NOTNLM ; Aluminum hydroxide gel (PubChem CID: 6328211) / Anti-CD40 Ab / Anti-OX40 Ab / B cells / Dinitrophenol (PubChem CID: 1493) / IgA / IgE / Mast cells / Ovalbumin (PubChem CID: 71311993)
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6. Popova NV: [Transplancental effect of ortho-aminoazotoluene on organ cultures of embryonal liver from mouse lines C57BL and CBA]. Biull Eksp Biol Med; 1977 Jun;83(6):732-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Transplancental effect of ortho-aminoazotoluene on organ cultures of embryonal liver from mouse lines C57BL and CBA].
  • [Transliterated title] Transplatsentarnoe deĭstvie orto-aminoazotuluola na organnye kul'tury émbrional'noĭ pecheni mysheĭ linii C57BL i CBA.
  • Transplacental influence of ortho-aminoazotoluol (OAAT) on the organ cultures of embryonal liver of highly-hepatomous mice CBA, and low-cancerous mice C57BL was the subject of this research.
  • Under the transplacental influence of 24 mg OAAT on CBA mice the toxic effect noted at the early cultivation period was replaced by the 20-25th cultivation days by the growth-stimulating effect.
  • [MeSH-minor] Animals. Female. Mice. Mice, Inbred C57BL. Mice, Inbred CBA. Neoplasms, Experimental. Organ Culture Techniques. Pregnancy. Species Specificity

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  • (PMID = 884303.001).
  • [ISSN] 0365-9615
  • [Journal-full-title] Biulleten' eksperimental'noĭ biologii i meditsiny
  • [ISO-abbreviation] Biull Eksp Biol Med
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] USSR
  • [Chemical-registry-number] 0 / Azo Compounds; QHZ900P7ZA / o-Aminoazotoluene
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7. Peng X, Wang J, Lassance-Soares RM, Najafi AH, Sood S, Aghili N, Alderman LO, Panza JA, Faber JE, Wang S, Epstein SE, Burnett MS: Gender differences affect blood flow recovery in a mouse model of hindlimb ischemia. Am J Physiol Heart Circ Physiol; 2011 Jun;300(6):H2027-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gender differences affect blood flow recovery in a mouse model of hindlimb ischemia.
  • The aim of this study was to examine gender effects on arteriogenesis and angiogenesis in a mouse ischemic hindlimb model.
  • C57BL/6J mice were subjected to unilateral hindlimb ischemia.
  • [MeSH-minor] Animals. Female. Male. Mice. Mice, Inbred C57BL. Models, Animal. Neovascularization, Physiologic / physiology. Nitric Oxide Synthase Type III / metabolism. Vascular Endothelial Growth Factor A / metabolism. Vascular Resistance / physiology

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  • (PMID = 21398592.001).
  • [ISSN] 1522-1539
  • [Journal-full-title] American journal of physiology. Heart and circulatory physiology
  • [ISO-abbreviation] Am. J. Physiol. Heart Circ. Physiol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL062584; United States / NHLBI NIH HHS / HL / R01 HL090655
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; EC 1.14.13.39 / Nitric Oxide Synthase Type III
  • [Other-IDs] NLM/ PMC3302196
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8. Sänger C, Schenk A, Schwen LO, Wang L, Gremse F, Zafarnia S, Kiessling F, Xie C, Wei W, Richter B, Dirsch O, Dahmen U: Intrahepatic Vascular Anatomy in Rats and Mice--Variations and Surgical Implications. PLoS One; 2015;10(11):e0141798

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrahepatic Vascular Anatomy in Rats and Mice--Variations and Surgical Implications.
  • We performed a detailed anatomical imaging study in rats and mice to allow for further refinement of experimental surgical approaches.
  • METHODS: LEWIS-Rats and C57Bl/6N-Mice were subjected to ex-vivo imaging using μCT.
  • CONCLUSIONS: For the first time the key variations of intrahepatic vascular anatomy in mice and rats and their surgical implications were described.
  • [MeSH-major] Liver / blood supply. Mice, Inbred C57BL / anatomy & histology. Rats, Inbred Lew / anatomy & histology
  • [MeSH-minor] Animals. Hepatic Artery / anatomy & histology. Hepatic Artery / surgery. Hepatic Veins / anatomy & histology. Hepatic Veins / surgery. Mice. Microvessels / anatomy & histology. Microvessels / surgery. Rats

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  • (PMID = 26618494.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4664386
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9. Burov IuV, Treskov VG, Kampov-Polevoĭ AB, Kovalenko AE, Rodionov AP: [Concentration of endogenous ethanol and alcoholic motivation]. Biull Eksp Biol Med; 1983 Nov;96(11):67-9
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  • Trials with patients suffering from stage II chronic alcoholism and normal test subjects as well as experiments made on male C57BL mice (with genetically determined alcoholic motivation) and CBA mice (with genetically determined alcoholic aversion) and random-bred male rats with different levels of initial alcoholic motivation have shown the presence of reverse proportional dependence between blood plasma endogenous ethanol and alcoholic motivation.
  • [MeSH-minor] Adult. Alcohol Drinking. Animals. Humans. Male. Mice. Mice, Inbred C57BL. Risk

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  • (PMID = 6640101.001).
  • [ISSN] 0365-9615
  • [Journal-full-title] Biulleten' eksperimental'noĭ biologii i meditsiny
  • [ISO-abbreviation] Biull Eksp Biol Med
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] USSR
  • [Chemical-registry-number] 3K9958V90M / Ethanol
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10. Seller MJ, Perkins-Cole KJ: Hyperthermia and neural tube defects of the curly-tail mouse. J Craniofac Genet Dev Biol; 1987;7(4):321-30
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  • [Title] Hyperthermia and neural tube defects of the curly-tail mouse.
  • The mutant gene curly-tail produces neural tube defects (NTD) in 60% of mice, predominantly at the caudal end of the neural tube.
  • Pregnant curly-tail mice and C57BL mice which are not genetically pre-disposed to NTD, were subjected to various regimes of hyperthermia on day 8 or on day 9 or on day 10 of gestation.
  • In C57BL mice, heat treatment produced exencephaly alone and in only 3% of mice.
  • In curly-tail mice, none of the heat-treatment regimes had any consistent effect on the incidence of posterior NTD but produced specifically exencephaly.
  • [MeSH-minor] Animals. Body Temperature Regulation. Female. Fetal Resorption / physiopathology. Mice. Mice, Inbred C57BL. Mice, Neurologic Mutants. Pregnancy

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  • (PMID = 3429610.001).
  • [ISSN] 0270-4145
  • [Journal-full-title] Journal of craniofacial genetics and developmental biology
  • [ISO-abbreviation] J. Craniofac. Genet. Dev. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
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11. Wang JS, Liu X, Xue ZY, Alderman L, Tilan JU, Adenika R, Epstein SE, Burnett MS: Effects of aging on time course of neovascularization-related gene expression following acute hindlimb ischemia in mice. Chin Med J (Engl); 2011 Apr;124(7):1075-81
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  • [Title] Effects of aging on time course of neovascularization-related gene expression following acute hindlimb ischemia in mice.
  • METHODS: Young (3-month) and old (18-month) C57Bl mice were subjected to left hindlimb ischemia.
  • RESULTS: MMP9, HIF-1α and SDF-1 were more upregulated during acute ischemia in old vs. young mice, reflecting increased ischemia in aging mice.
  • However VEGF and eNOS exhibited lower expression in old vs. young mice, despite greater ischemia intensity.
  • Ang1 and Flk1 showed similar expression in old vs. young mice.
  • MMP9 peaked earlier in peripheral blood in young vs. old mice.
  • [MeSH-minor] Animals. Blotting, Western. Chemokine CXCL12 / metabolism. Female. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Matrix Metalloproteinase 9 / metabolism. Mice. Mice, Inbred C57BL. Muscle, Skeletal / metabolism. Muscle, Skeletal / pathology. Necrosis / metabolism. Necrosis / pathology. Necrosis / physiopathology. Vascular Endothelial Growth Factor A / genetics. Vascular Endothelial Growth Factor A / metabolism. Vascular Endothelial Growth Factor Receptor-1 / genetics. Vascular Endothelial Growth Factor Receptor-1 / metabolism

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  • (PMID = 21542971.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Chemokine CXCL12; 0 / Cxcl12 protein, mouse; 0 / Hif1a protein, mouse; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Flt1 protein, mouse; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-1; EC 3.4.24.35 / Matrix Metalloproteinase 9
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12. Cheung LP, Leung HY, Bongso A: Effect of supplementation of leukemia inhibitory factor and epidermal growth factor on murine embryonic development in vitro, implantation, and outcome of offspring. Fertil Steril; 2003 Sep;80 Suppl 2:727-35

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  • SUBJECT(S): Two-cell embryos from F1(CBA x C57BL) mice.
  • [MeSH-minor] Animals. Blastocyst / cytology. Blastocyst / drug effects. Blastocyst / physiology. Crosses, Genetic. Culture Media / pharmacology. Embryo Transfer. Female. Leukemia Inhibitory Factor. Male. Mice. Mice, Inbred C57BL. Mice, Inbred CBA. Pregnancy. Pregnancy Outcome. Prospective Studies. Random Allocation

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  • (PMID = 14505746.001).
  • [ISSN] 0015-0282
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Culture Media; 0 / Growth Inhibitors; 0 / Interleukin-6; 0 / Leukemia Inhibitory Factor; 0 / Lif protein, mouse; 0 / Lymphokines; 62229-50-9 / Epidermal Growth Factor
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13. Schreiber RA, Santos NN: Audiogenic seizures and brain extracts: enhancement by extracts from C57BL/6J mice subjected to audiogenic priming. Pharmacol Biochem Behav; 1977 May;6(5):603-5
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  • [Title] Audiogenic seizures and brain extracts: enhancement by extracts from C57BL/6J mice subjected to audiogenic priming.
  • Donor C57BL/6J mice were given audiogenic priming (AP) by exposure to noise at 16 days of age (To) and sacrificed at intervals from 1 hr to 18 days therafter.
  • Brains from AP and littermate non-AP mice were extracted in 1 M acetic acid, and passed through a filter with a nominal mol. wt. cutoff of 10,000 daltons.
  • Recipient C57BL/6J mice were also exposed to 30 sec of 127 +/- 2 dBA at 16 days of age, and injected IP with one brain-equivalent of extracts from either AP or non-AP donors immediately therafter.
  • Recipient convulsion rates were higher in AP relative to non-AP extract-injected mice whenAP donors were sacrificed 1 to 18 days after To.
  • [MeSH-minor] Animals. Mice. Mice, Inbred C57BL. Time Factors

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  • (PMID = 896896.001).
  • [ISSN] 0091-3057
  • [Journal-full-title] Pharmacology, biochemistry, and behavior
  • [ISO-abbreviation] Pharmacol. Biochem. Behav.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Tissue Extracts
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14. Darnerud PO, Brandt I, Feil VJ, Bakke JE: Dichlorovinyl cysteine (DCVC) in the mouse kidney: tissue-binding and toxicity after glutathione depletion and probenecid treatment. Arch Toxicol; 1989;63(5):345-50
Hazardous Substances Data Bank. PROBENECID .

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  • [Title] Dichlorovinyl cysteine (DCVC) in the mouse kidney: tissue-binding and toxicity after glutathione depletion and probenecid treatment.
  • The kidney binding of dichloro[14C]vinyl cysteine (14C-DCVC, 8 mg/kg body wt) and the kidney histopathology of DCVC (5 mg/kg body wt) were examined and compared in female C57BL mice subjected to various treatments.
  • To evaluate the roles of organic anion transport and glutathione (GSH) status, mice were pretreated with probenecid (inhibitor of organic anion transport), L-buthionine-S,R-sulfoximine (BSO; inhibitor of GSH synthesis) or with diethyl maleate (DEM; GSH-depleting agent).
  • In addition, the sites of 14C-DCVC binding in BSO-treated and control mice were monitored by microautoradiography.
  • In BSO-treated mice, DCVC binding remained roughly unchanged, whereas nephrotoxicity was severely increased and topographically extended to the subcapsular region.
  • In DEM-treated mice, a clearly decreased DCVC binding was observed, while the effect on nephrotoxicity was minute.
  • The effects of probenecid on DCVC binding and toxicity support a role for carrier-mediated transport of DCVC equivalents into the target cells.
  • In the case of DEM it is proposed that a DEM-GSH conjugate might compete for the uptake and/or activation of DCVC in the target cells.
  • [MeSH-minor] Animals. Autoradiography. Cysteine / metabolism. Female. Kidney Tubules / metabolism. Mice. Mice, Inbred C57BL. Sulfhydryl Compounds / metabolism

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  • [Cites] J Biol Chem. 1979 Aug 25;254(16):7558-60 [38242.001]
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  • (PMID = 2818197.001).
  • [ISSN] 0340-5761
  • [Journal-full-title] Archives of toxicology
  • [ISO-abbreviation] Arch. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Sulfhydryl Compounds; 627-72-5 / S-(1,2-dichlorovinyl)cysteine; GAN16C9B8O / Glutathione; K848JZ4886 / Cysteine; PO572Z7917 / Probenecid
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15. González R, Carbajal D, Wyczolkowska J: The effect of disodium 4-chloro-2-iminodibenzoate (CCA) on IgE levels and anaphylactic shock. Agents Actions; 1989 Nov;28(3-4):168-72
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  • The effect of disodium 4-chloro-2,2-iminodibenzoate (CCA) on IgE antibody response was examined in C3H/A and (BALB/c x C57BL/6J) F1 hybrid mice immunized with low doses of ovalbumin (OA) adsorbed on aluminium hydroxide gel.
  • CCA administered orally at the doses of 5 and 50 mg/kg/day reduced IgE antibody production in these mice as determined by PCA test.
  • High doses of CCA (100 mg/kg/day) given from day 7 before immunization of C57BL mice and during 1 week after immunization of mice with OA and Bordetella Pertussis Vaccine reduced the mortality of these mice subjected to anaphylactic shock on day 7 of immunization.
  • CCA treatment was ineffective in anaphylactic shock of C57BL mice immunized with very high dose of OA, known to elicit little or no IgE antibody production but high IgG antibody response.
  • Our results demonstrate that CCA inhibits IgE production as well as IgE mediated hypersensitivity reactions in mice.
  • [MeSH-minor] Animals. Antigens / immunology. Female. Guinea Pigs. Immunization. Immunoglobulin G / immunology. Male. Mice. Mice, Inbred C3H. Ovalbumin / immunology

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  • [Cites] Annu Rev Immunol. 1988;6:513-34 [3289576.001]
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  • (PMID = 2596370.001).
  • [ISSN] 0065-4299
  • [Journal-full-title] Agents and actions
  • [ISO-abbreviation] Agents Actions
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antigens; 0 / Immunoglobulin G; 0 / Immunosuppressive Agents; 0 / ortho-Aminobenzoates; 37341-29-0 / Immunoglobulin E; 9006-59-1 / Ovalbumin; 915EE91P39 / lobenzarit
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16. Cui M, Wang L, Liang X, Ma X, Liu Y, Yang M, Liu K, Wei X, Zhou Z, Chen YH, Sun W: Blocking TRAIL-DR5 signaling with soluble DR5 reduces delayed neuronal damage after transient global cerebral ischemia. Neurobiol Dis; 2010 Aug;39(2):138-47
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  • C57BL/6j mice were subjected to transient global brain ischemia.
  • [MeSH-minor] Animals. Apoptosis / drug effects. Brain / drug effects. Brain / pathology. DNA Fragmentation / drug effects. Disease Models, Animal. Gene Expression Regulation / drug effects. Gene Expression Regulation / physiology. Glial Fibrillary Acidic Protein / metabolism. In Situ Nick-End Labeling / methods. Male. Mice. Mice, Inbred C57BL. Neural Cell Adhesion Molecules / metabolism. Statistics, Nonparametric

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  • (PMID = 20359534.001).
  • [ISSN] 1095-953X
  • [Journal-full-title] Neurobiology of disease
  • [ISO-abbreviation] Neurobiol. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Neural Cell Adhesion Molecules; 0 / Receptors, TNF-Related Apoptosis-Inducing Ligand; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / Tnfrsf10b protein, mouse; 0 / Tnfsf10 protein, mouse
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17. Parra A, McGirt MJ, Sheng H, Laskowitz DT, Pearlstein RD, Warner DS: Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis. Neurol Res; 2002 Jul;24(5):510-6
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  • [Title] Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis.
  • The transgenic mouse has been used to study subarachnoid hemorrhage (SAH) induced delayed cerebral vasospasm (DCV).
  • C57BL/6J mice were subjected to SAH or sham surgery.
  • Mice were perfused with and without microfiltration.
  • Additional mice underwent grading of SAH size, measurement of vascular diameters, and neurological examination (score range 5-27; 27= normal).
  • This allows measurement of both anatomical and clinical DCV in the mouse.
  • [MeSH-minor] Animals. Body Weight / physiology. Cerebrovascular Circulation / physiology. Disease Models, Animal. Hydrostatic Pressure / adverse effects. Ink. Mice. Mice, Inbred C57BL. Micropore Filters / standards. Predictive Value of Tests. Reproducibility of Results

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  • (PMID = 12117325.001).
  • [ISSN] 0161-6412
  • [Journal-full-title] Neurological research
  • [ISO-abbreviation] Neurol. Res.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS38944-03; United States / NIGMS NIH HHS / GM / T35-GM08679
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
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18. Schreiber RA: Time course of protection from audiogenic seizures by glucose and insulin in audiogenically primed C57BL/6J mice. Pharmacol Biochem Behav; 1978 May;8(5):619-21
Hazardous Substances Data Bank. GLUCOSE .

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  • [Title] Time course of protection from audiogenic seizures by glucose and insulin in audiogenically primed C57BL/6J mice.
  • Glucose and insulin injections both decrease seizure susceptibility in C57BL/6J mice subjected to audiogenic priming at 16 days of age and tested at 21 days of age.
  • These data support an hypothesis of defect in immediately available energy reserves in brains of audiogenic seizure prone mice.
  • [MeSH-minor] Acoustic Stimulation. Animals. Blood Glucose / metabolism. Mice. Mice, Inbred C57BL. Time Factors

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  • (PMID = 674268.001).
  • [ISSN] 0091-3057
  • [Journal-full-title] Pharmacology, biochemistry, and behavior
  • [ISO-abbreviation] Pharmacol. Biochem. Behav.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Anticonvulsants; 0 / Blood Glucose; 0 / Insulin; IY9XDZ35W2 / Glucose
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19. Sandberg JO, Andersson A, Eizirik DL, Sandler S: Interleukin-1 receptor antagonist prevents low dose streptozotocin induced diabetes in mice. Biochem Biophys Res Commun; 1994 Jul 15;202(1):543-8
The Lens. Cited by Patents in .

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  • [Title] Interleukin-1 receptor antagonist prevents low dose streptozotocin induced diabetes in mice.
  • The effect of the interleukin-1 receptor antagonist (IL-1ra) on development of hyperglycemia and insulitis in mice treated with multiple low doses of streptozotocin (STZ) was evaluated.
  • C57BL/Ks mice were subjected to the following treatments:.
  • [MeSH-minor] Animals. Blood Glucose / metabolism. Cells, Cultured. Dose-Response Relationship, Drug. Interleukin 1 Receptor Antagonist Protein. Male. Mice. Mice, Inbred C57BL. Rats. Rats, Sprague-Dawley. Reference Values. Streptozocin / administration & dosage. Time Factors

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  • (PMID = 8037760.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Il1rn protein, mouse; 0 / Insulin; 0 / Interleukin 1 Receptor Antagonist Protein; 0 / Receptors, Interleukin-1; 0 / Sialoglycoproteins; 5W494URQ81 / Streptozocin
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20. Fu P, Murley JS, Grdina DJ, Birukova AA, Birukov KG: Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury. Crit Care Med; 2011 Dec;39(12):2711-21
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  • Amifostine attenuates oxidative stress and improves lipopolysaccharide-induced lung injury by acting as a direct scavenger of reactive oxygen and nitrogen species.
  • DESIGN: Randomized and controlled laboratory investigation in mice and cell culture.
  • SUBJECTS: C57BL/6J mice.
  • INTERVENTIONS: Mice received once-daily dosing with amifostine (10-100 mg/kg, intraperitoneal injection) 3 days consecutively before high tidal volume ventilation (30 mL/kg, 4 hrs) at day 4.
  • CONCLUSIONS: Amifostine preconditioning activates lung tissue antioxidant cell defense mechanisms and may be a promising strategy for alleviation of ventilator-induced lung injury in critically ill patients subjected to extended mechanical ventilation.

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  • [CommentIn] Crit Care Med. 2012 May;40(5):1693-4 [22511172.001]
  • [CommentIn] Crit Care Med. 2011 Dec;39(12):2776-7 [22094514.001]
  • (PMID = 21765345.001).
  • [ISSN] 1530-0293
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL89257; United States / NHLBI NIH HHS / HL / R01 HL107920; United States / NHLBI NIH HHS / HL / R01 HL076259; United States / NCRR NIH HHS / RR / UL1 RR024999; United States / NCI NIH HHS / CA / R01 CA099005; United States / NHLBI NIH HHS / HL / R01 HL089257; United States / NHLBI NIH HHS / HL / HL087823; United States / NHLBI NIH HHS / HL / HL076259; United States / NHLBI NIH HHS / HL / R01 HL087823; United States / NCRR NIH HHS / RR / UL1RR024999; United States / PHS HHS / / P01-058064; United States / NCI NIH HHS / CA / R01 CA99005; United States / NHLBI NIH HHS / HL / P01 HL058064
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Free Radical Scavengers; 0 / Reactive Oxygen Species; M487QF2F4V / Amifostine
  • [Other-IDs] NLM/ NIHMS463061; NLM/ PMC3657468
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21. Knappe T, Mittlmeier T, Eipel C, Amon M, Menger MD, Vollmar B: Effect of systemic hypothermia on local soft tissue trauma-induced microcirculatory and cellular dysfunction in mice. Crit Care Med; 2005 Aug;33(8):1805-13
MedlinePlus Health Information. consumer health - Hypothermia.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of systemic hypothermia on local soft tissue trauma-induced microcirculatory and cellular dysfunction in mice.
  • SUBJECTS: C57BL/6J mice.
  • [MeSH-minor] Animals. Apoptosis. Blood Flow Velocity. Cell Adhesion. Leukocytes. Male. Mice. Mice, Inbred C57BL. Microcirculation. Microscopy, Fluorescence. Soft Tissue Injuries / complications. Soft Tissue Injuries / physiopathology

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  • [CommentIn] Crit Care Med. 2005 Aug;33(8):1879-81 [16096479.001]
  • (PMID = 16096459.001).
  • [ISSN] 0090-3493
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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22. Heiman ML, Ahima RS, Craft LS, Schoner B, Stephens TW, Flier JS: Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Endocrinology; 1997 Sep;138(9):3859-63
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Absence of the mature hormone is responsible for the obese phenotype of ob/ob mice.
  • The hypothalamic-pituitary-adrenal axis (HPAA) is activated in ob/ob mice, and chronic administration of leptin to ob/ob mice decreases plasma corticosterone levels, suggesting that the adipose hormone is capable of inhibiting the HPAA.
  • The aim of this study was to determine whether leptin feeds back acutely to inhibit the HPAA of normal mice and rats.
  • Male C57BL mice were injected ip with 100 microl saline and 2 or 4 microg/g BW mouse leptin in saline vehicle, and 4 h later they were subjected to 2 h of restraint stress by taping the hind limbs together or no stress.
  • Pretreatment with recombinant mouse leptin blocked the stress-mediated stimulation of both plasma hormones.
  • This response was blocked by mouse leptin in a dose-dependent manner (integrated stimulated CRH secretion was 30.6 +/- 2.5 pg/2 h, n = 5; 20.5 +/- 3.6 pg/2 h, n = 7; 15.3 +/- 4.3 pg/2 h, n = 3 for 1 nM, 3 nM and 30 nM, respectively).
  • [MeSH-minor] Adrenocorticotropic Hormone / blood. Adrenocorticotropic Hormone / secretion. Animals. Cells, Cultured. Corticosterone / blood. Corticotropin-Releasing Hormone / secretion. Feedback. Glucose / pharmacology. Hypothalamus / drug effects. Hypothalamus / secretion. In Vitro Techniques. Leptin. Male. Mice. Mice, Inbred C57BL. Pituitary Gland / drug effects. Pituitary Gland / secretion. Rats. Rats, Sprague-Dawley. Restraint, Physical

  • Hazardous Substances Data Bank. GLUCOSE .
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  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
  • Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .
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  • (PMID = 9275075.001).
  • [ISSN] 0013-7227
  • [Journal-full-title] Endocrinology
  • [ISO-abbreviation] Endocrinology
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK-28082
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Leptin; 0 / Proteins; 9002-60-2 / Adrenocorticotropic Hormone; 9015-71-8 / Corticotropin-Releasing Hormone; IY9XDZ35W2 / Glucose; W980KJ009P / Corticosterone
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23. Israelsson C, Bengtsson H, Kylberg A, Kullander K, Lewén A, Hillered L, Ebendal T: Distinct cellular patterns of upregulated chemokine expression supporting a prominent inflammatory role in traumatic brain injury. J Neurotrauma; 2008 Aug;25(8):959-74

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We subjected C57BL/6J mice to injury by controlled cortical impact (CCI).
  • [MeSH-minor] Animals. Antigens, CD11c / genetics. Antigens, CD11c / metabolism. Cluster Analysis. Dendritic Cells / physiology. Mice. Mice, Inbred C57BL. Microglia / physiology. RNA, Messenger / metabolism

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  • (PMID = 18665806.001).
  • [ISSN] 0897-7151
  • [Journal-full-title] Journal of neurotrauma
  • [ISO-abbreviation] J. Neurotrauma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD11c; 0 / Chemokines; 0 / RNA, Messenger
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24. Jadhav V, Ostrowski RP, Tong W, Matus B, Jesunathadas R, Zhang JH: Cyclo-oxygenase-2 mediates hyperbaric oxygen preconditioning-induced neuroprotection in the mouse model of surgical brain injury. Stroke; 2009 Sep;40(9):3139-42
MedlinePlus Health Information. consumer health - Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclo-oxygenase-2 mediates hyperbaric oxygen preconditioning-induced neuroprotection in the mouse model of surgical brain injury.
  • BACKGROUND AND PURPOSE: We investigated the role of cyclo-oxygenase-2 (COX-2) in mechanisms of hyperbaric oxygen preconditioning (HBO-PC) in the mouse model of surgical brain injury (SBI).
  • METHODS: C57BL mice were administered 100% oxygen for 1 hour at 2.5 atmosphere absolute for 5 consecutive days and subjected to SBI.

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  • (PMID = 19628811.001).
  • [ISSN] 1524-4628
  • [Journal-full-title] Stroke; a journal of cerebral circulation
  • [ISO-abbreviation] Stroke
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / NS53407; United States / NINDS NIH HHS / NS / R01 NS053407; United States / NICHD NIH HHS / HD / R01 HD043120; United States / NINDS NIH HHS / NS / NS043338-05; United States / NICHD NIH HHS / HD / R01 HD043120-05; United States / NICHD NIH HHS / HD / HD43120; United States / NINDS NIH HHS / NS / NS43338; United States / NINDS NIH HHS / NS / R01 NS043338; United States / NINDS NIH HHS / NS / R01 NS043338-05
  • [Publication-type] Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclooxygenase Inhibitors; 0 / Hif1a protein, mouse; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Nitrobenzenes; 0 / Sulfonamides; 123653-11-2 / N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; EC 1.14.99.- / Ptgs2 protein, mouse; EC 1.14.99.1 / Cyclooxygenase 2
  • [Other-IDs] NLM/ NIHMS139840; NLM/ PMC2798800
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25. Nakagata N, Okamoto M, Ueda O, Suzuki H: Positive effect of partial zona-pellucida dissection on the in vitro fertilizing capacity of cryopreserved C57BL/6J transgenic mouse spermatozoa of low motility. Biol Reprod; 1997 Nov;57(5):1050-5
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Positive effect of partial zona-pellucida dissection on the in vitro fertilizing capacity of cryopreserved C57BL/6J transgenic mouse spermatozoa of low motility.
  • Although cryopreservation of mouse spermatozoa has recently become available for use, as yet there are considerable differences in fertilization efficiency of cryopreserved spermatozoa among various mouse strains.
  • In this study, oocytes subjected to partial dissection of the zona pellucida (PZD) were inseminated with frozen-thawed C57BL/6J mouse spermatozoa.
  • When the cryopreserved spermatozoa of C57BL/6J transgenic mice were used to fertilize PZD oocytes, the fertilization rates were as high as (73-76%) those of the PZD oocytes inseminated with the cryopreserved C57BL/6J spermatozoa, with 30-31% of the morulae and early blastocysts derived from the monospermatic oocytes developing into offspring.
  • These results indicate that PZD of oocytes may provide an alternative when the fertilizing capacity of mouse spermatozoa has been compromised by cryopreservation.
  • [MeSH-minor] Animals. Cryopreservation. Female. Male. Mice. Mice, Inbred C57BL. Mice, Transgenic. Oocytes / drug effects. Oocytes / ultrastructure

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  • (PMID = 9369169.001).
  • [ISSN] 0006-3363
  • [Journal-full-title] Biology of reproduction
  • [ISO-abbreviation] Biol. Reprod.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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26. Kim D, Hwang E, Lee M, Sung H, Choi JH: Characterization of topographically specific sleep spindles in mice. Sleep; 2015 Jan;38(1):85-96

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of topographically specific sleep spindles in mice.
  • In this study, we aim to investigate the electrophysiological behaviors of the topographically distinctive spindles within the thalamocortical system by applying high-density EEG and simultaneous thalamic LFP recordings in mice.
  • DESIGN: 32-channel extracranial EEG and 2-channel thalamic LFP were recorded simultaneously in freely behaving mice to acquire spindles during spontaneous sleep.
  • SUBJECTS: Hybrid F1 male mice of C57BL/6J and 129S4/svJae.
  • [MeSH-minor] Algorithms. Animals. Cerebral Cortex / physiology. Cluster Analysis. Electroencephalography. Male. Mice. Mice, Inbred C57BL. Thalamus / physiology

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  • [Copyright] © 2014 Associated Professional Sleep Societies, LLC.
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  • (PMID = 25325451.001).
  • [ISSN] 1550-9109
  • [Journal-full-title] Sleep
  • [ISO-abbreviation] Sleep
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4262960
  • [Keywords] NOTNLM ; high-density EEG / mouse / sleep slow waves / sleep spindles / thalamic LFP / thalamocortical networks / topography
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27. Shimizu H, Obase Y, Katoh S, Mouri K, Kobashi Y, Oka M: Critical role of interleukin-5 in the development of a mite antigen-induced chronic bronchial asthma model. Inflamm Res; 2013 Oct;62(10):911-7
MedlinePlus Health Information. consumer health - Asthma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUBJECTS: In this study, 48 female C57BL/6J (WT) mice and IL-5 receptor-deficient (IL-5RKO) mice were used.
  • TREATMENT: Mite antigen (50 μl) was intranasally administered 13 times to WT and IL-5RKO mice.
  • RESULTS: Airway sensitivity was enhanced and antigen-specific airway resistance was increased in WT mice.
  • In contrast, IL-5RKO mice did not acquire the asthma pathology, such as antigen-specific airway resistance and eosinophilic airway inflammation.
  • Mch PC200 was significantly correlated with cysteinyl leukotriene levels in WT mice.
  • [MeSH-minor] Airway Resistance / immunology. Animals. Bronchoalveolar Lavage Fluid / cytology. Bronchoalveolar Lavage Fluid / immunology. Cytokines / immunology. Eosinophils / cytology. Female. Immunoglobulin E / blood. Immunoglobulin G / blood. Leukocyte Count. Leukotrienes / immunology. Mice. Mice, Inbred C57BL. Mice, Knockout. Receptors, Interleukin-5 / genetics. Receptors, Interleukin-5 / immunology

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  • (PMID = 23942524.001).
  • [ISSN] 1420-908X
  • [Journal-full-title] Inflammation research : official journal of the European Histamine Research Society ... [et al.]
  • [ISO-abbreviation] Inflamm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, Dermatophagoides; 0 / Cytokines; 0 / Immunoglobulin G; 0 / Interleukin-5; 0 / Leukotrienes; 0 / Receptors, Interleukin-5; 37341-29-0 / Immunoglobulin E
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28. Del Val GM, Robledano PM: In vivo serial sampling of epididymal sperm in mice. Lab Anim; 2013 Jul;47(3):168-74

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In vivo serial sampling of epididymal sperm in mice.
  • This study was undertaken to refine the techniques of in vivo collection of sperm in the mouse.
  • The principal objective was to offer a viable, safe and reliable method for serial collection of in vivo epididimary sperm through the direct puncture of the epididymis.
  • Six C57Bl/6J males were subjected to the whole experiment.
  • After that, the animals were subjected another time to the same process (sampling, recover and natural mating).
  • This study documented the feasibility of the epididimary puncture technique to in vivo serial sampling of sperm in the mouse.
  • [MeSH-major] Epididymis / surgery. Mice / surgery. Sperm Retrieval. Urologic Surgical Procedures, Male / methods
  • [MeSH-minor] Animals. Female. Fertilization. Fertilization in Vitro. Male. Mice, Inbred C57BL. Spermatozoa

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  • (PMID = 23760960.001).
  • [ISSN] 1758-1117
  • [Journal-full-title] Laboratory animals
  • [ISO-abbreviation] Lab. Anim.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; 3 Rs / In vivo / epididymal / in vitro fertilization (IVF) / refinement / sampling / serial / sperm
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29. Dieterich HJ, Weissmüller T, Rosenberger P, Eltzschig HK: Effect of hydroxyethyl starch on vascular leak syndrome and neutrophil accumulation during hypoxia. Crit Care Med; 2006 Jun;34(6):1775-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUBJECTS: Cultured human microvascular endothelial cells and mice (C57BL/6/129 svj).
  • Increases of tissue neutrophil accumulation following hypoxia exposure were dampened in hydroxyethyl starch-treated mice.
  • [MeSH-minor] Acute Disease. Animals. Cell Adhesion / drug effects. Cells, Cultured. Disease Models, Animal. Humans. In Vitro Techniques. Mice. Mice, Inbred C57BL. Syndrome. Umbilical Veins / cytology

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  • (PMID = 16625120.001).
  • [ISSN] 0090-3493
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hydroxyethyl Starch Derivatives; 0 / Plasma Substitutes
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30. Longoni R, Spina L, Vinci S, Acquas E: The MEK inhibitor SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study. Psychopharmacology (Berl); 2011 Jul;216(1):63-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: C57BL/6J mice were subjected to lithium (150 mg/kg)-induced CPA.
  • To assess whether ERK is activated by acute lithium and, in distinct experiments, during CPA expression, mice were sacrificed, 30 min after lithium, and immediately after post-conditioning test, respectively, for pERK immunohistochemistry.
  • In addition, the post-conditioning test of lithium-conditioned mice determined a significant increase of pERK-positive neurons in the dorsal striatum and SL327 (50 mg/kg), administered before post-conditioning test, while failing at the doses of 25, 50, and 100 mg/kg, to affect lithium-induced CPA expression, completely prevented it.
  • [MeSH-minor] Animals. Corpus Striatum / drug effects. Corpus Striatum / enzymology. Immunohistochemistry. Male. Mice. Mice, Inbred C57BL

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  • (PMID = 21312031.001).
  • [ISSN] 1432-2072
  • [Journal-full-title] Psychopharmacology
  • [ISO-abbreviation] Psychopharmacology (Berl.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / SL 327; 3739OQ10IJ / Aminoacetonitrile; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; G4962QA067 / Lithium Chloride
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31. Cheney KE, Liu RK, Smith GS, Leung RE, Mickey MR, Walford RL: Survival and disease patterns in C57BL/6J mice subjected to undernutrition. Exp Gerontol; 1980;15(4):237-58

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival and disease patterns in C57BL/6J mice subjected to undernutrition.
  • [MeSH-major] Diet. Longevity. Mice, Inbred C57BL / physiology. Neoplasms / prevention & control
  • [MeSH-minor] Aging. Animals. Computers. Female. Lymphoma / prevention & control. Male. Mice. Sex Factors. Statistics as Topic

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  • (PMID = 7409023.001).
  • [ISSN] 0531-5565
  • [Journal-full-title] Experimental gerontology
  • [ISO-abbreviation] Exp. Gerontol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / 5T01-GM-802; United States / NIA NIH HHS / AG / AG-00424; United States / NCRR NIH HHS / RR / RR-3
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] ENGLAND
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32. Jadhav V, Ostrowski RP, Tong W, Matus B, Chang C, Zhang JH: Hyperbaric oxygen preconditioning reduces postoperative brain edema and improves neurological outcomes after surgical brain injury. Acta Neurochir Suppl; 2010;106:217-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The present study was designed to examine if hyperbaric oxygen preconditioning (HBO-PC) is neuroprotective in a mouse model of surgical brain injury (SBI).
  • C57BL mice were administered 100% oxygen for 1 h at 2.5 ATA for 5 consecutive days and subjected to SBI on the following day.
  • [MeSH-minor] Analysis of Variance. Animals. Blood-Brain Barrier / physiopathology. Disease Models, Animal. Functional Laterality. Mice. Mice, Inbred C57BL. Neurologic Examination / methods. Time Factors

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  • (PMID = 19812952.001).
  • [ISSN] 0065-1419
  • [Journal-full-title] Acta neurochirurgica. Supplement
  • [ISO-abbreviation] Acta Neurochir. Suppl.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS 43338; United States / NINDS NIH HHS / NS / NS 45694; United States / NINDS NIH HHS / NS / NS 53407
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Austria
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33. Barkhausen T, Tschernig T, Rosenstiel P, van Griensven M, Vonberg RP, Dorsch M, Mueller-Heine A, Chalaris A, Scheller J, Rose-John S, Seegert D, Krettek C, Waetzig GH: Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model. Crit Care Med; 2011 Jun;39(6):1407-13
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUBJECTS: C57BL/6J mice.
  • In the 96-hr study, CLP was performed in 120 randomized mice (20 mice received vehicle, 10 mice per dose group).
  • Mice were treated with equimolar doses of sgp130Fc (0.01/0.1/1/10 mg/kg) or anti-IL-6 (0.008/0.08/0.8/8 mg/kg) 24 hrs before CLP.
  • In the 24-hr study, mice were randomized into four groups with 10 animals each (sham/vehicle, CLP/vehicle, CLP/anti-IL-6 [0.8 mg/kg], and CLP/sgp130Fc [1 mg/kg]) and killed after 24 hrs.
  • [MeSH-minor] Animals. Disease Models, Animal. Dose-Response Relationship, Drug. Male. Mice. Mice, Inbred C57BL. Signal Transduction / drug effects

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  • [CommentIn] Crit Care Med. 2011 Jun;39(6):1582-3 [21610636.001]
  • (PMID = 21336117.001).
  • [ISSN] 1530-0293
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neutralizing; 0 / Interleukin-6; 0 / Recombinant Fusion Proteins; 0 / Sgp130Fc protein
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34. Hou X, Liang X, Chen JF, Zheng J: Ecto-5'-nucleotidase (CD73) is involved in chronic cerebral hypoperfusion-induced white matter lesions and cognitive impairment by regulating glial cell activation and pro-inflammatory cytokines. Neuroscience; 2015 Jun 25;297:118-26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the present study, we investigated the expression and activity of CD73 using immunohistochemistry, Western blot analysis and measurements of the rate of AMP hydrolysis in a mouse model of CCH via bilateral common carotid artery stenosis (BCAS) surgery.
  • Moreover, C57BL/6-CD73 knockout (KO) and their wild-type littermates were subjected to BCAS surgery to further investigate the functional roles of CD73 in the WMLs.
  • More reactive astrocytes and microglia were observed in the corpus callosum in CD73-KO mice.
  • [MeSH-minor] Adenosine Monophosphate / metabolism. Analysis of Variance. Animals. Corpus Callosum / metabolism. Corpus Callosum / pathology. Disease Models, Animal. Enzyme-Linked Immunosorbent Assay. Gene Expression Regulation / genetics. Memory, Short-Term / physiology. Mice. Mice, Knockout

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  • [Copyright] Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 25805696.001).
  • [ISSN] 1873-7544
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 415SHH325A / Adenosine Monophosphate; EC 3.1.3.5 / 5'-Nucleotidase
  • [Keywords] NOTNLM ; Ecto-5′-nucleotidase (CD73) / chronic cerebral hypoperfusion / cognitive impairment / proinflammatory cytokine / white matter lesions
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35. Castanares-Zapatero D, Bouleti C, Sommereyns C, Gerber B, Lecut C, Mathivet T, Horckmans M, Communi D, Foretz M, Vanoverschelde JL, Germain S, Bertrand L, Laterre PF, Oury C, Viollet B, Horman S, Beauloye C: Connection between cardiac vascular permeability, myocardial edema, and inflammation during sepsis: role of the α1AMP-activated protein kinase isoform. Crit Care Med; 2013 Dec;41(12):e411-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUBJECTS: C57BL/6J, α1AMPK, and α1AMPK mice.
  • Left ventricular function, edema, vascular permeability, and inflammation were assessed in vivo in both wild-type mice (α1AMPK) and α1AMP-activated protein kinase-deficient mice (α1AMPK).
  • Accordingly, AMP-activated protein kinase activation by aminoimidazole-4-carboxamide riboside counteracted lipopolysaccharide-induced hyperpermeability in wild-type mice in vivo as well as in endothelial cells in vitro.
  • [MeSH-minor] Aminoimidazole Carboxamide / analogs & derivatives. Aminoimidazole Carboxamide / pharmacology. Animals. Cells, Cultured. Coloring Agents / pharmacokinetics. Cytokines / blood. Echocardiography. Endothelial Cells / drug effects. Evans Blue / pharmacokinetics. Gene Silencing. Heart Ventricles / physiopathology. Humans. Lipopolysaccharides / pharmacology. Lung / enzymology. Magnetic Resonance Imaging. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Peroxidase / metabolism. Ribonucleosides / pharmacology. Tight Junctions / drug effects

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  • (PMID = 23963133.001).
  • [ISSN] 1530-0293
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Cytokines; 0 / Lipopolysaccharides; 0 / Ribonucleosides; 360-97-4 / Aminoimidazole Carboxamide; 45PG892GO1 / Evans Blue; 53IEF47846 / acadesine; EC 1.11.1.7 / Peroxidase; EC 2.7.11.1 / AMP-Activated Protein Kinases
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36. Vandendriessche B, Peperstraete H, Rogge E, Cauwels P, Hoste E, Stiedl O, Brouckaert P, Cauwels A: A multiscale entropy-based tool for scoring severity of systemic inflammation. Crit Care Med; 2014 Aug;42(8):e560-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • DESIGN: Linear (time and frequency domain) and nonlinear (unifractal and multiscale complexity dynamics) measures of beat-to-beat interval variability were analyzed in two mouse models of inflammatory shock to determine if they are sensitive enough to predict outcome.
  • SUBJECTS: Blood pressure transmitter-implanted female C57BL/6J mice.
  • [MeSH-minor] Animals. Blood Pressure. Early Diagnosis. Female. Heart Rate. Lipopolysaccharides. Mice. Mice, Inbred C57BL. Prognosis. Survival Rate. Treatment Outcome. Tumor Necrosis Factor-alpha

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  • [CommentIn] Crit Care Med. 2014 Aug;42(8):1964 [25029145.001]
  • (PMID = 24717467.001).
  • [ISSN] 1530-0293
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipopolysaccharides; 0 / Tumor Necrosis Factor-alpha
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37. Fiorito C, Balestrieri ML, Crimi E, Giovane A, Grimaldi V, Minucci PB, Servillo L, D'Armiento FP, Farzati B, Napoli C: Effect of L-arginine on circulating endothelial progenitor cells and VEGF after moderate physical training in mice. Int J Cardiol; 2008 Jun 6;126(3):421-3
Hazardous Substances Data Bank. (L)-ARGININE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of L-arginine on circulating endothelial progenitor cells and VEGF after moderate physical training in mice.
  • Here, we aimed to evaluate the effects of L-arginine on EPC levels in C57BL/6J mice subjected to moderate physical exercise.
  • [MeSH-minor] Analysis of Variance. Animals. Enzyme-Linked Immunosorbent Assay. Mice. Mice, Inbred C57BL. Models, Animal. Physical Conditioning, Animal. Probability. Random Allocation. Sensitivity and Specificity

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  • (PMID = 18243372.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; 94ZLA3W45F / Arginine
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38. Nakamura K, Doi K, Okamoto K, Arai S, Ueha S, Matsushima K, Nakajima S, Yahagi N, Noiri E: Specific antibody in IV immunoglobulin for postsplenectomy sepsis. Crit Care Med; 2013 Aug;41(8):e163-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUBJECTS: Male C57BL/6JJcl mice.
  • INTERVENTIONS: Mice underwent splenectomy or a sham operation at 8 weeks old.
  • At 4 weeks after the operation, mice were injected intravenously with 106 colony-forming units pneumococcus.
  • MEASUREMENTS AND MAIN RESULTS: IV immunoglobulin markedly improved splenectomized mice survival.
  • Fluorescence microscopy results indicated significantly increased phagocytosis of antibody-bound bacteria in the livers of splenectomized mice treated with intact IV immunoglobulins.
  • [MeSH-minor] Animals. B-Lymphocytes / cytology. Bacterial Load. Blood / microbiology. Cytokines / blood. Flow Cytometry. Immunoprecipitation. Liver / microbiology. Liver / pathology. Male. Mice. Mice, Inbred C57BL. Microscopy, Fluorescence. Phagocytosis / drug effects. Prospective Studies. Random Allocation. Spleen / cytology. Spleen / microbiology. Streptococcus pneumoniae / immunology

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  • (PMID = 23863254.001).
  • [ISSN] 1530-0293
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Cytokines; 0 / Immunoglobulins, Intravenous; 0 / Immunologic Factors
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39. Sulila P, Holmdahl R, Hansson I, Bernadotte F, Mattsson A, Mattsson R: An investigation of allogeneic pregnancy in multiparous mice subjected to in vivo depletion of CD8 (Ly2)-positive lymphocytes by monoclonal antibody treatment. J Reprod Immunol; 1988 Dec;14(3):235-45

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An investigation of allogeneic pregnancy in multiparous mice subjected to in vivo depletion of CD8 (Ly2)-positive lymphocytes by monoclonal antibody treatment.
  • Adult thymectomized C57/Bl (H-2b) and DBA/1 (H-2q) female mice were subjected to treatment with rat anti-mouse CD8 and mouse anti-rat Ig (kappa) prior to entering their third pregnancy with CBA/Ca (H-2k) males.
  • All mice were investigated on day 18 of their third gestation.
  • However, the formation of anti-paternal antibodies was enhanced in anti-CD8 treated C57/Bl mice.
  • [MeSH-minor] Animals. Antibodies, Monoclonal. Antibody-Producing Cells / immunology. Antigens, CD8. Antigens, Differentiation, T-Lymphocyte. Antigens, Ly. Female. Isoantibodies / biosynthesis. Lymphoid Tissue / anatomy & histology. Mice. Mice, Inbred Strains. Parity. Pregnancy. T-Lymphocytes / immunology

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  • (PMID = 2906368.001).
  • [ISSN] 0165-0378
  • [Journal-full-title] Journal of reproductive immunology
  • [ISO-abbreviation] J. Reprod. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, CD8; 0 / Antigens, Differentiation, T-Lymphocyte; 0 / Antigens, Ly; 0 / Isoantibodies
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40. Akamatsu Y: Casein and 3-methylcholanthrene carcinogenesis in inbred C57BL/6Os female mice. J Natl Cancer Inst; 1976 Dec;57(6):1367-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Casein and 3-methylcholanthrene carcinogenesis in inbred C57BL/6Os female mice.
  • Groups of inbred C57BL/6Os female mice were subjected to one of the following -reatments:.
  • During their life-spans, mice of the C group developed a significantly high incidence of neoplasms, especially histiocytic lymphomas, No myelogenous leukemia was observed in the C group, but it was seen in the MCA, C-MCA, and MCA-C groups.
  • Results suggested that sodium caseinate treatment shifts target organs in MCA carcinogenesis.
  • [MeSH-minor] Amyloidosis / chemically induced. Animals. Female. Leukemia, Experimental / chemically induced. Lymphoma, Non-Hodgkin / chemically induced. Mice. Mice, Inbred C57BL. Neoplasms, Experimental / chemically induced

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  • (PMID = 794506.001).
  • [ISSN] 0027-8874
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Caseins; 56-49-5 / Methylcholanthrene
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41. Guo W, Jiang T, Lian C, Wang H, Zheng Q, Ma H: QKI deficiency promotes FoxO1 mediated nitrosative stress and endoplasmic reticulum stress contributing to increased vulnerability to ischemic injury in diabetic heart. J Mol Cell Cardiol; 2014 Oct;75:131-40
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  • Diabetic ob/ob mice or wild-type C57BL/6J mice were subjected to in vivo myocardial I/R.
  • Obvious NS stress was observed in the myocardium of ob/ob mice represented by elevated iNOS expression, total NO content and nitrotyrosine content.
  • Upregulation of QKI5 diminished FoxO1 expression together with NS and ER stress in ob/ob myocardium, further reducing MI/R injury.
  • [MeSH-minor] Animals. Apoptosis. Down-Regulation. Gene Knockdown Techniques. Humans. Male. Mice, Inbred C57BL. Mice, Obese. Myocardial Reperfusion Injury / complications. Myocardial Reperfusion Injury / pathology. Myocardium / metabolism. Myocardium / pathology. Myocytes, Cardiac / pathology. Nitrosation. Protein Stability. RNA, Messenger / genetics. RNA, Messenger / metabolism. Up-Regulation

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  • [Copyright] Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
  • (PMID = 25068621.001).
  • [ISSN] 1095-8584
  • [Journal-full-title] Journal of molecular and cellular cardiology
  • [ISO-abbreviation] J. Mol. Cell. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Forkhead Transcription Factors; 0 / Foxo1 protein, mouse; 0 / Qk protein, mouse; 0 / RNA, Messenger; 0 / RNA-Binding Proteins
  • [Keywords] NOTNLM ; Diabetes / FoxO1 / Ischemia/reperfusion injury / RNA binding protein QKI
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42. Bitto A, Minutoli L, David A, Irrera N, Rinaldi M, Venuti FS, Squadrito F, Altavilla D: Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis. Crit Care; 2012;16(1):R32
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  • [Title] Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis.
  • METHODS: C57BL/6J mice were subjected to CLP or sham operation.
  • Furthermore, additional groups of sham and CLP mice were killed 18 hours after surgical procedures for blood-sample collection and the lung and liver were collected for biomolecular, biochemical and histopathologic studies.
  • CONCLUSIONS: Flavocoxid protects mice from sepsis, suggesting that this dual inhibitor may represent a promising approach in such a life-threatening condition.
  • [MeSH-minor] Animals. Arrestins / metabolism. Cytokines / blood. Cytokines / metabolism. Dinoprostone / blood. Disease Models, Animal. Drug Combinations. Extracellular Signal-Regulated MAP Kinases / metabolism. Intracellular Signaling Peptides and Proteins / metabolism. Leukotriene B4 / blood. Lipoxins / blood. Liver / metabolism. Liver / pathology. Lung / metabolism. Lung / pathology. Mice, Inbred C57BL. NF-kappa B / blood. Peroxidase / metabolism

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  • (PMID = 22356547.001).
  • [ISSN] 1466-609X
  • [Journal-full-title] Critical care (London, England)
  • [ISO-abbreviation] Crit Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arrestins; 0 / Cyclooxygenase 2 Inhibitors; 0 / Cytokines; 0 / Drug Combinations; 0 / Intracellular Signaling Peptides and Proteins; 0 / Lipoxins; 0 / Lipoxygenase Inhibitors; 0 / Mapkbp1 protein, mouse; 0 / NF-kappa B; 0 / beta-arrestin; 0 / flavocoxid; 0 / lipoxin A4; 1HGW4DR56D / Leukotriene B4; 8R1V1STN48 / Catechin; EC 1.11.1.7 / Peroxidase; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; K7Q1JQR04M / Dinoprostone
  • [Other-IDs] NLM/ PMC3396211
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43. Yamane H, Sakai A, Mori T, Tanaka S, Moridera K, Nakamura T: The anabolic action of intermittent PTH in combination with cathepsin K inhibitor or alendronate differs depending on the remodeling status in bone in ovariectomized mice. Bone; 2009 Jun;44(6):1055-62
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  • [Title] The anabolic action of intermittent PTH in combination with cathepsin K inhibitor or alendronate differs depending on the remodeling status in bone in ovariectomized mice.
  • C57/BL/6J mice, 8 weeks of age, were subjected to ovariectomized (OVX) or sham surgery.
  • At 6 weeks after surgery, the mice were treated with cathepsin K inhibitor, alendronate, or a vehicle (daily, for 8 weeks), with or without PTH (1-34) (5 times/week, for the last 4 weeks).
  • This study demonstrated that alendronate enhances the anabolic action of PTH at the primary spongiosa, but blunts it in the remodeling trabecular bone, while cathepsin K inhibitor enhances the action at both sites in OVX mice.
  • In conclusion, the anabolic action of intermittent PTH in combination with cathepsin K inhibitor or alendronate differs depending on the remodeling status of bone in OVX mice.
  • [MeSH-minor] Animals. Apoptosis / drug effects. Body Weight / drug effects. Bone Density / drug effects. Cathepsin K. Cells, Cultured. Creatine / urine. Enzyme-Linked Immunosorbent Assay. Female. Mice. Mice, Inbred C57BL. Osteocalcin / blood. Osteoclasts / cytology. Osteoclasts / drug effects. Reverse Transcriptase Polymerase Chain Reaction. Tibia / cytology. Tibia / drug effects

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  • (PMID = 19303837.001).
  • [ISSN] 1873-2763
  • [Journal-full-title] Bone
  • [ISO-abbreviation] Bone
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 104982-03-8 / Osteocalcin; EC 3.4.- / Cathepsins; EC 3.4.22.38 / Cathepsin K; EC 3.4.22.38 / Ctsk protein, mouse; MU72812GK0 / Creatine; X1J18R4W8P / Alendronate
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44. Kida K, Marutani E, Nguyen RK, Ichinose F: Inhaled hydrogen sulfide prevents neuropathic pain after peripheral nerve injury in mice. Nitric Oxide; 2015 Apr 30;46:87-92
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  • [Title] Inhaled hydrogen sulfide prevents neuropathic pain after peripheral nerve injury in mice.
  • In this study, we examined the effects of hydrogen sulfide breathing on neuropathic pain in mice.
  • C57BL/6J mice were subjected to chronic constriction injury (CCI) of the sciatic nerve.
  • After CCI, mice breathed air alone or air mixed with hydrogen sulfide at 40 ppm for 8 h on 7 consecutive days.
  • Mice that breathed air alone exhibited the neuropathic pain behavior including mechanical allodynia and thermal hyperalgesia and increased mRNA levels of IL-6 and chemokine CC motif ligand 2 (CCL2) after CCI.
  • These results suggest that inhaled hydrogen sulfide prevents the development of neuropathic pain in mice possibly via inhibition of the activation of microglia in the spinal cord.

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  • [Copyright] Copyright © 2014 Elsevier Inc. All rights reserved.
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  • (PMID = 25461302.001).
  • [ISSN] 1089-8611
  • [Journal-full-title] Nitric oxide : biology and chemistry
  • [ISO-abbreviation] Nitric Oxide
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL101930; United States / PHS HHS / / NHLBI HL101930
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics; 0 / Interleukin-6; YY9FVM7NSN / Hydrogen Sulfide
  • [Other-IDs] NLM/ NIHMS650706; NLM/ PMC4361306
  • [Keywords] NOTNLM ; Hydrogen sulfide / Inflammatory cytokine / Microglia / Neuropathic pain
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45. Jang Y, Yeom MY, Kang ES, Kang JW, Song HK: The antinociceptive effect of dexmedetomidine modulates spleen cell immunity in mice. Int J Med Sci; 2014;11(3):226-33
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  • [Title] The antinociceptive effect of dexmedetomidine modulates spleen cell immunity in mice.
  • METHODS: After evaluation of the analgesic efficacy of dexmedetomidine in C57BL mice that were subjected to formalin-induced pain, dexmedetomidine (30 µg/kg) or saline was injected intraperitoneally (ip) 30 min before formalin (20 µL of 2% formalin in 0.9% saline) injection.
  • Various numbers of effector cells (NK cells) were added to the wells of a microtiter plate containing 2 × 10(4) target YAC-1 cells in 100 μL, to achieve final effector-to-target cell ratios of 80:1, 40:1, and 20:1.
  • Formalin-induced pain led to higher activity of NK cells than in sham-treated mice (p <0.05), but NK activity was not increased significantly by ip dexmedetomidine treatment.
  • Formalin-induced pain alters cellular immunity of spleen in mice.
  • [MeSH-minor] Animals. Formaldehyde / toxicity. Interleukin-10 / metabolism. Killer Cells, Natural / drug effects. Killer Cells, Natural / immunology. Lymphocytes / immunology. Lymphocytes / metabolism. Mice. Spleen / cytology. Spleen / drug effects

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  • (PMID = 24516345.001).
  • [ISSN] 1449-1907
  • [Journal-full-title] International journal of medical sciences
  • [ISO-abbreviation] Int J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Analgesics; 130068-27-8 / Interleukin-10; 1HG84L3525 / Formaldehyde; 67VB76HONO / Dexmedetomidine
  • [Other-IDs] NLM/ PMC3917109
  • [Keywords] NOTNLM ; Antinociceptive Effect / Cell Immunity / Dexmedetomidine / Mice
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46. Kohsaka A, Das P, Hashimoto I, Nakao T, Deguchi Y, Gouraud SS, Waki H, Muragaki Y, Maeda M: The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice. PLoS One; 2014;9(11):e112811
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

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  • [Title] The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice.
  • Mice without cardiac Bmal1 function show a significant decrease in the expression of genes associated with the fatty acid oxidative pathway, the tricarboxylic acid cycle, and the mitochondrial respiratory chain in the heart and develop severe progressive heart failure with age.
  • Importantly, similar changes in gene expression related to mitochondrial oxidative metabolism are also observed in C57BL/6J mice subjected to chronic reversal of the light-dark cycle; thus, they show disrupted circadian rhythmicity.
  • [MeSH-minor] 3-Hydroxyacyl CoA Dehydrogenases / metabolism. ARNTL Transcription Factors / metabolism. Acetyl-CoA C-Acyltransferase / metabolism. Animals. CLOCK Proteins / metabolism. Carbon-Carbon Double Bond Isomerases / metabolism. Citric Acid Cycle / physiology. Electron Transport / physiology. Enoyl-CoA Hydratase / metabolism. Gene Expression / physiology. Male. Mice. Mice, Inbred C57BL. Photoperiod. Racemases and Epimerases / metabolism

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  • (PMID = 25389966.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ARNTL Transcription Factors; 0 / fatty acid oxidation complex; EC 1.1.1.- / 3-Hydroxyacyl CoA Dehydrogenases; EC 2.3.1.16 / Acetyl-CoA C-Acyltransferase; EC 2.3.1.48 / CLOCK Proteins; EC 4.2.1.17 / Enoyl-CoA Hydratase; EC 5.1.- / Racemases and Epimerases; EC 5.3.3.- / Carbon-Carbon Double Bond Isomerases
  • [Other-IDs] NLM/ PMC4229239
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47. Yoda M, Nakano Y, Tobe T, Shioda S, Choi-Miura NH, Tomita M: Characterization of mouse GBP28 and its induction by exposure to cold. Int J Obes Relat Metab Disord; 2001 Jan;25(1):75-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of mouse GBP28 and its induction by exposure to cold.
  • OBJECTIVE: To investigate whether the expression of the novel adipose tissue-specific protein GBP28 in adipose tissue and serum are altered in mice under a variety of conditions.
  • DESIGN: Mice were fed a high-fat diet for 4 weeks, fasted for 48 h or exposed at 4 degrees C.
  • SUBJECTS: C57BL/6J mouse, male, 4--6 weeks old.
  • MEASUREMENTS: GBP28 mRNA, GBP28 protein, blood glucose, insulin and fad pad weight of the mice.
  • RESULTS: We first confirmed that the mouse has GBP28 and its characteristics are the same as human GBP28.
  • Serum concentration and mRNA levels of GBP28 significantly increased in the mice exposed to cold.
  • [MeSH-minor] Adiponectin. Adipose Tissue / metabolism. Amino Acid Sequence. Animals. Basal Metabolism. Blood Glucose / analysis. Blotting, Northern. Blotting, Western. Electrophoresis, Polyacrylamide Gel. Fasting. Food Deprivation / physiology. Homeostasis. Immunohistochemistry. Insulin / blood. Male. Mice. Mice, Inbred C57BL. Obesity / metabolism. Protein Biosynthesis. RNA, Messenger / analysis

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  • (PMID = 11244461.001).
  • [Journal-full-title] International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
  • [ISO-abbreviation] Int. J. Obes. Relat. Metab. Disord.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Blood Glucose; 0 / Dietary Fats; 0 / Insulin; 0 / Intercellular Signaling Peptides and Proteins; 0 / Proteins; 0 / RNA, Messenger
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48. Dupont J, Aubert R, Kuan SI, Warner DA, Camus MC, Herzog J: Hepatic hydroxymethylglutaryl coenzyme A reductase activity in inbred strains of mice. Enzyme; 1988;40(4):198-203
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  • [Title] Hepatic hydroxymethylglutaryl coenzyme A reductase activity in inbred strains of mice.
  • Mice are available in numerous genetic strains and could be a useful inexpensive animal model for studying diet and genetic interactions in the regulation of cholesterol metabolism.
  • Obese and non-obese C57BL/6J, CBA/J, and obese and non-obese DW dbPas mice were subjected to variations in light cycle, feeding schedule, and pectin and fat composition of their diets.
  • The mice responded in the same ways as rats to light cycle, feeding pattern, and sex difference.
  • We conclude that mice will, indeed, offer an excellent animal model for the study of cholesterol metabolism regulation.
  • [MeSH-major] Hydroxymethylglutaryl CoA Reductases / metabolism. Mice, Inbred Strains / metabolism. Microsomes, Liver / enzymology
  • [MeSH-minor] Animals. Circadian Rhythm. Dietary Fats. Female. Lipids / analysis. Liver / analysis. Male. Mice. Mice, Inbred C57BL / metabolism. Mice, Inbred CBA / metabolism. Mice, Obese / metabolism. Sex Factors

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  • (PMID = 3234319.001).
  • [ISSN] 0013-9432
  • [Journal-full-title] Enzyme
  • [ISO-abbreviation] Enzyme
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] SWITZERLAND
  • [Chemical-registry-number] 0 / Dietary Fats; 0 / Lipids; EC 1.1.1.- / Hydroxymethylglutaryl CoA Reductases
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49. Hwang BH, Kunkler PE, Tarricone BJ, Hingtgen JN, Nurnberger JI Jr: Stress-induced changes of norepinephrine uptake sites in the locus coeruleus of C57BL/6J and DBA/2J mice: a quantitative autoradiographic study using [3H]-tomoxetine. Neurosci Lett; 1999 Apr 23;265(3):151-4
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  • [Title] Stress-induced changes of norepinephrine uptake sites in the locus coeruleus of C57BL/6J and DBA/2J mice: a quantitative autoradiographic study using [3H]-tomoxetine.
  • Inbred C57BL/6J (C57) and DBA/2J (DBA) mice were subjected to open-field evaluation and Porsolt swim test after restraint stress.
  • Norepinephrine (NE) uptake sites in the locus coeruleus (LC) of these inbred mice were studied by using [3H]-tomoxetine.
  • Results showed that naive C57 mice were more active in the open field and possessed more NE uptake sites in the LC than naive DBA mice.
  • Previous work has shown that restraint decreases open field activity in C57 mice, but not DBA mice, whereas the present study has demonstrated that, after restraint stress, C57 mice spent more time immobile than DBA mice did in the forced swim test.
  • Furthermore, in these stressed animals, NE uptake sites in the LC were greatly increased with consistently more uptake sites in C57 mice.
  • Collectively, results of this study and the literature suggest that enhanced NE function in the LC of C57 mice is associated with their susceptibility to stress-induced behavioral depression.
  • [MeSH-minor] Animals. Atomoxetine Hydrochloride. Autoradiography. Brain Chemistry / physiology. Male. Mice. Mice, Inbred C57BL. Mice, Inbred DBA. Receptors, Adrenergic / metabolism. Restraint, Physical. Species Specificity. Swimming. Tritium. Up-Regulation / physiology

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  • (PMID = 10327153.001).
  • [ISSN] 0304-3940
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS-25087
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] IRELAND
  • [Chemical-registry-number] 0 / Antidepressive Agents; 0 / Propylamines; 0 / Receptors, Adrenergic; 10028-17-8 / Tritium; 57WVB6I2W0 / Atomoxetine Hydrochloride; X4W3ENH1CV / Norepinephrine
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50. Liu X, Guo CY, Ma XJ, Wu CF, Zhang Y, Sun MY, Pan YT, Yin HJ: Anti-inflammatory effects of tanshinone IIA on atherosclerostic vessels of ovariectomized ApoE mice are mediated by estrogen receptor activation and through the ERK signaling pathway. Cell Physiol Biochem; 2015;35(5):1744-55
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  • [Title] Anti-inflammatory effects of tanshinone IIA on atherosclerostic vessels of ovariectomized ApoE mice are mediated by estrogen receptor activation and through the ERK signaling pathway.
  • METHODS: Subjects for this study were 120 apoE(-/-) female mice and 20 C57/BL female mice.
  • The apoE(-/-) mice were ovariectomized (OVX) and the C57/BL mice were sham ovariectomized.
  • The sham OVX mice were maintained on a normal diet (NOR) group.
  • The OVX apoE(-/-) mice were fed a high fat diet and randomly divided into 6 groups: Model (MOD) group which was fed a high fat diet only, E2 group were given estrogen (E2) 0.13 mg/kg/d; E2+ICI group were given E2:0.13 mg/kg/d and ICI182780:65 mg/kg/m; TLD group (TanIIA low dose) were given TanIIA: 30 mg/kg/d; THD group (TanIIA high dose) were given TanIIA:60 mg/kg/d; and TLD+ICI group were given TanIIA 30 mg/kg/d and ICI182780 65 mg/kg/m.
  • After three months of treatment, the aorta and the blood of the mice from each group was collected.
  • CONCLUSION: Tanshinone IIA may play an anti-inflammatory and anti-oxidative stress role in OVX atherosclerotic apoE(-/-) mice by activating the estrogen receptor through the ERK signaling pathway.
  • [MeSH-minor] Animals. Apolipoproteins E / deficiency. Apolipoproteins E / genetics. Apolipoproteins E / metabolism. Atherosclerosis / metabolism. Atherosclerosis / pathology. Diet, High-Fat. Disease Models, Animal. Estradiol / blood. Estrogens / pharmacology. Female. Mice. Mice, Inbred C57BL. Mice, Knockout. NF-kappa B / metabolism. Ovariectomy. Oxidative Stress / drug effects. Superoxide Dismutase / blood. Triglycerides / blood

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  • [Copyright] © 2015 S. Karger AG, Basel.
  • (PMID = 25832326.001).
  • [ISSN] 1421-9778
  • [Journal-full-title] Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
  • [ISO-abbreviation] Cell. Physiol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Apolipoproteins E; 0 / Diterpenes, Abietane; 0 / Estrogens; 0 / NF-kappa B; 0 / Receptors, Estrogen; 0 / Triglycerides; 03UUH3J385 / tanshinone; 4TI98Z838E / Estradiol; EC 1.15.1.1 / Superoxide Dismutase; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
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51. Huber R, Deboer T, Tobler I: Effects of sleep deprivation on sleep and sleep EEG in three mouse strains: empirical data and simulations. Brain Res; 2000 Feb 28;857(1-2):8-19
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  • [Title] Effects of sleep deprivation on sleep and sleep EEG in three mouse strains: empirical data and simulations.
  • Gene targeted mice can be used as models to investigate the mechanisms underlying sleep regulation.
  • Three commonly used background strains for gene targeting (129/Ola, 129/SvJ and C57BL/6J) were subjected to 4-h and 6-h sleep deprivation (SD), and their sleep and sleep EEG were continuously recorded.
  • We tested the capacity of the model to predict SWA in nonREM sleep on the basis of the temporal organization of sleep in mice.
  • Simulations of the time course of SWA were successful for 129/SvJ and C57BL/6J, but were not satisfactory for 129/Ola.
  • Since the time constants are assumed to reflect the dynamics of the physiological processes involved in sleep regulation, the results provide a basis for the use of gene targeted mice to investigate the underlying mechanisms.
  • [MeSH-minor] Animals. Circadian Rhythm / physiology. Electroencephalography. Mice. Mice, Inbred Strains. Models, Neurological. Time Factors

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  • (PMID = 10700548.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] NETHERLANDS
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52. Veasey SC, Davis CW, Fenik P, Zhan G, Hsu YJ, Pratico D, Gow A: Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions. Sleep; 2004 Mar 15;27(2):194-201
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  • [Title] Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions.
  • DESIGN: Sleep times and oxidative-injury parameters were compared for mice exposed to LTIH and mice exposed to sham LTIH.
  • SUBJECTS: Adult male C57BL/6J mice were studied.
  • INTERVENTIONS: Mice were exposed to LTIH or sham LTIH in the lights-on period daily for 8 weeks.
  • MEASUREMENTS AND RESULTS: At both intervals, total sleep time per 24 hours in LTIH-exposed mice was increased by more than 2 hours, (P<.01).
  • Mean sleep latency was reduced in LTIH-exposed mice relative to sham LTIH mice (8.9 +/- 1.0 minutes vs 12.7 +/- 0.5 minutes, respectively, P<.01).
  • [MeSH-minor] Animals. Electrodes, Implanted. Immunohistochemistry. Lipid Peroxidation / physiology. Male. Mice. Mice, Inbred C57BL. Prosencephalon / physiopathology

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  • [CommentIn] Sleep. 2004 Mar 15;27(2):186-7 [15124708.001]
  • (PMID = 15124711.001).
  • [ISSN] 0161-8105
  • [Journal-full-title] Sleep
  • [ISO-abbreviation] Sleep
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL65225; United States / CSR NIH HHS / RG / IIRG-02-4010
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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53. Zyromski NJ, Mathur A, Pitt HA, Lu D, Gripe JT, Walker JJ, Yancey K, Wade TE, Swartz-Basile DA: A murine model of obesity implicates the adipokine milieu in the pathogenesis of severe acute pancreatitis. Am J Physiol Gastrointest Liver Physiol; 2008 Sep;295(3):G552-8
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  • Lean (C57BL/6J), obese leptin-deficient (LepOb), and obese hyperleptinemic (LepDb) mice were subjected to AP by six hourly intraperitoneal injections of cerulein (50 microg/kg).
  • Both congenitally obese strains of mice developed significantly more severe AP than wild-type lean animals.
  • Severity of AP was not solely related to adipose tissue volume: LepOb mice were heaviest; however, LepDb mice developed the most severe AP both histologically and biochemically.
  • These data demonstrate that congenitally obese mice develop more severe AP than lean animals when challenged by cerulein hyperstimulation and suggest that alteration of the adipokine milieu exacerbates the severity of AP in obesity.
  • [MeSH-minor] Acute Disease. Adiponectin / metabolism. Amylases / blood. Animals. Blood Glucose / metabolism. Body Weight. Ceruletide. Chemokines / metabolism. Cytokines / metabolism. Disease Models, Animal. Female. Insulin / blood. Leptin / metabolism. Lung / enzymology. Mice. Mice, Inbred C57BL. Mice, Obese. Peroxidase / metabolism. Severity of Illness Index

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  • (PMID = 18583460.001).
  • [ISSN] 0193-1857
  • [Journal-full-title] American journal of physiology. Gastrointestinal and liver physiology
  • [ISO-abbreviation] Am. J. Physiol. Gastrointest. Liver Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adipokines; 0 / Adiponectin; 0 / Adipoq protein, mouse; 0 / Blood Glucose; 0 / Chemokines; 0 / Cytokines; 0 / Insulin; 0 / Leptin; 888Y08971B / Ceruletide; EC 1.11.1.7 / Peroxidase; EC 3.2.1.- / Amylases
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54. Balestrieri ML, Fiorito C, Crimi E, Felice F, Schiano C, Milone L, Casamassimi A, Giovane A, Grimaldi V, del Giudice V, Minucci PB, Mancini FP, Servillo L, D'Armiento FP, Farzati B, Napoli C: Effect of red wine antioxidants and minor polyphenolic constituents on endothelial progenitor cells after physical training in mice. Int J Cardiol; 2008 May 23;126(2):295-7
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  • [Title] Effect of red wine antioxidants and minor polyphenolic constituents on endothelial progenitor cells after physical training in mice.
  • Here, we evaluate the effects of red wine (RW) on EPCs in C57BL/6J mice subjected to physical exercise.
  • FACS computed counting showed a significant increase of EPC number (P<0.05) in mice after short-term supplementation with RW.
  • [MeSH-minor] Animals. Cell Proliferation / drug effects. Mice. Mice, Inbred C57BL. Polyphenols

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  • (PMID = 18255172.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Flavonoids; 0 / Phenols; 0 / Polyphenols
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55. Mascareno E, Beckles D, Dhar-Mascareno M, Siddiqui MA: Enhanced hypertrophy in ob/ob mice due to an impairment in expression of atrial natriuretic peptide. Vascul Pharmacol; 2009 Aug-Sep;51(2-3):198-204
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  • [Title] Enhanced hypertrophy in ob/ob mice due to an impairment in expression of atrial natriuretic peptide.
  • To this end, ob/ob leptin deficient and C57BL/6J control mice were subjected transverse aortic constriction (TAC).
  • METHODS: Control sham C57BL/6J and ob/ob mice, along with C57BL/6J and ob/ob leptin deficient mice were subjected transverse aortic constriction (TAC) for 15 days and then evaluated for morphological, physiological, and molecular changes associated with pressure overload hypertrophy.
  • RESULTS: Evaluation by echocardiography revealed a significant increase in left ventricular mass (LVmass) and wall thickness in ob/ob mice subjected to transverse aortic constriction (TAC) as compared to C57BL/6J.
  • Analysis of the expression of molecular markers of LVH, such as atrial natriuretic peptide (ANP), revealed a blunted increase in the level of ANP in ob/ob mice as compared to C57BL/6J mice.
  • Our in vivo studies revealed that ob/ob mice subjected to TAC failed to activate the NFATc4 in the heart, however, intraperitoneal injection of leptin in ob/ob mice restored the NFATc4 DNA-binding activity and induced expression of the ANP gene.

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  • (PMID = 19560554.001).
  • [ISSN] 1879-3649
  • [Journal-full-title] Vascular pharmacology
  • [ISO-abbreviation] Vascul. Pharmacol.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL073399; None / None / / R01 HL073399-04; United States / NHLBI NIH HHS / HL / HL073399; United States / NHLBI NIH HHS / HL / R01 HL073399-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcineurin Inhibitors; 0 / DNA-Binding Proteins; 0 / Genetic Markers; 0 / Leptin; 0 / NFATC Transcription Factors; 85637-73-6 / Atrial Natriuretic Factor
  • [Other-IDs] NLM/ NIHMS128153; NLM/ PMC2747368
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56. Szklarczyk K, Korostynski M, Cieslak PE, Wawrzczak-Bargiela A, Przewlocki R: Opioid-dependent regulation of high and low fear responses in two inbred mouse strains. Behav Brain Res; 2015 Oct 1;292:95-101
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Opioid-dependent regulation of high and low fear responses in two inbred mouse strains.
  • Here, we aimed to analyze the contribution of the opioid system to fear responses in two inbred mouse strains exhibiting distinct behavioral phenotypes.
  • SWR/J and C57BL/6J mice were subjected to five consecutive electric footshocks (1mA each), and the contextual freezing time was measured.
  • SWR/J mice did not develop conditioned fear but exhibited increased transcriptional expression of Pdyn and Penk in the amygdala region.
  • The C57BL/6J strain displayed high conditioned fear, although no alteration in the mRNA abundance of genes encoding opioid precursors was observed.
  • [MeSH-minor] Amygdala / drug effects. Amygdala / physiology. Animals. Behavior, Animal / drug effects. Behavior, Animal / physiology. Conditioning, Classical. Enkephalins / biosynthesis. Enkephalins / genetics. Gene Expression / drug effects. Genetic Association Studies. Hippocampus / drug effects. Hippocampus / physiology. Male. Mice. Mice, Inbred C57BL. Mice, Inbred Strains. Naltrexone / analogs & derivatives. Naltrexone / pharmacology. Protein Precursors / biosynthesis. Protein Precursors / genetics. Random Allocation. Receptors, Opioid / agonists. Stress, Psychological / genetics. Stress, Psychological / psychology

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  • [Copyright] Copyright © 2015 Elsevier B.V. All rights reserved.
  • (PMID = 26051817.001).
  • [ISSN] 1872-7549
  • [Journal-full-title] Behavioural brain research
  • [ISO-abbreviation] Behav. Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Enkephalins; 0 / Protein Precursors; 0 / Receptors, Opioid; 111555-53-4 / naltrindole; 5S6W795CQM / Naltrexone; 93443-35-7 / preproenkephalin
  • [Keywords] NOTNLM ; Amygdala / Animal models / Delta receptor / Fear conditioning / Opioids / Posttraumatic stress disorder
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57. Ackland GL, Kazymov V, Marina N, Singer M, Gourine AV: Peripheral neural detection of danger-associated and pathogen-associated molecular patterns. Crit Care Med; 2013 Jun;41(6):e85-92
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  • SUBJECTS: C57Bl/6J mice; juvenile Sprague-Dawley rats, primary human neutrophils.
  • In mice, systemic inflammation was induced by the pathogen associated molecular pattern zymosan (intraperitoneal injection; 500 mg/kg).
  • [MeSH-minor] Animals. Calcium / metabolism. Disease Models, Animal. Humans. Lipopolysaccharides / pharmacology. Mice. Mice, Inbred C57BL. Neutrophils. Random Allocation. Rats. Rats, Sprague-Dawley. Zymosan / pharmacology

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  • (PMID = 23507714.001).
  • [ISSN] 1530-0293
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 095064; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Inflammation Mediators; 0 / Lipopolysaccharides; 0 / Toll-Like Receptors; 9010-72-4 / Zymosan; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC4154842
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58. McMellen ME, Wakeman D, Erwin CR, Guo J, Warner BW: Epidermal growth factor receptor signaling modulates chemokine (CXC) ligand 5 expression and is associated with villus angiogenesis after small bowel resection. Surgery; 2010 Aug;148(2):364-70
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • METHODS: C57BL/6J mice were subjected to sham operation (bowel transaction with reanastomosis) or 50% proximal SBR.

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
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  • (PMID = 20471049.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK059288-07; United States / NCI NIH HHS / CA / T32 CA009621; United States / NIDDK NIH HHS / DK / DK059288-07; United States / NIDDK NIH HHS / DK / R01 DK059288; United States / NIDDK NIH HHS / DK / R01 DK 059288; United States / NIDDK NIH HHS / DK / P30 DK52574; United States / NIDDK NIH HHS / DK / P30 DK052574; United States / NCI NIH HHS / CA / 2T32CA009621-21
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chemokine CXCL5; 0 / Cxcl5 protein, mouse; 0 / RNA, Messenger; 62229-50-9 / Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ NIHMS192913; NLM/ PMC2917230
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59. Okada H, Ikeda T, Kajita K, Mori I, Hanamoto T, Fujioka K, Yamauchi M, Usui T, Takahashi N, Kitada Y, Taguchi K, Uno Y, Morita H, Wu Z, Nagano I, Takahashi Y, Kudo T, Furuya K, Yamada T, Ishizuka T: Effect of nematode Trichinella infection on glucose tolerance and status of macrophage in obese mice. Endocr J; 2013;60(11):1241-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of nematode Trichinella infection on glucose tolerance and status of macrophage in obese mice.
  • Ob/ob mice and high fat-fed mice (obesity model) and C57/BL mice (control mice) were orally infected with (infected group) or without (uninfected group) 400 Trichinella per mouse.
  • Four weeks later, the mice were subjected to investigation, which showed that fasting plasma glucose levels decreased in the infected group of C57/BL and ob/ob mice.
  • Glucose tolerance, evaluated with intraperitoneal GTT, improved in the infected group of ob/ob mice and high fat-fed mice compared with the uninfected groups.
  • The result showed that mRNA levels of M2 markers, such as CD206, arginase and IL-10, increased, whereas M1 markers, such as CD11c, iNOS and IL-6, decreased in the stromal vascular fraction (SVF) isolated from epididymal fat in ob/ob mice.
  • Trichinella infection increases the ratio of M2/M1 systemically, which results in an improvement in pro-inflammatory state in adipose tissue and amelioration of glucose tolerance in obese mice.
  • [MeSH-minor] Adipocytes / metabolism. Adipose Tissue / metabolism. Animals. Mice. Mice, Inbred C57BL. Mice, Obese

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  • (PMID = 23985691.001).
  • [ISSN] 1348-4540
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Blood Glucose
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60. Lee KH, Lim D, Green T, Greenhalgh D, Cho K: Injury-elicited stressors alter endogenous retrovirus expression in lymphocytes depending on cell type and source lymphoid organ. BMC Immunol; 2013 Jan 05;14:2
MedlinePlus Health Information. consumer health - Burns.

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  • BACKGROUND: Murine leukemia virus-type endogenous retroviruses (MuLV-ERVs) constitute ~10% of the mouse genome and are associated with various pathophysiologic processes.
  • RESULTS: B- and T-cells, which were sorted from nine lymphoid organs of C57BL/6J mice after burn, were subjected to MuLV-ERV expression analyses.

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  • (PMID = 23289855.001).
  • [ISSN] 1471-2172
  • [Journal-full-title] BMC immunology
  • [ISO-abbreviation] BMC Immunol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM071360
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3562510
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61. Woodske ME, Yokoe T, Zou B, Romano LC, Rosa TC, Garcia-Ocana A, Alonso LC, O'Donnell CP, McVerry BJ: Hyperinsulinemia predicts survival in a hyperglycemic mouse model of critical illness. Crit Care Med; 2009 Sep;37(9):2596-603
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyperinsulinemia predicts survival in a hyperglycemic mouse model of critical illness.
  • SUBJECTS: : Male C57BL/6J mice, 8-12 wks old.
  • INTERVENTIONS: : Spontaneously breathing mice were instrumented with chronic indwelling arterial and venous catheters.
  • Mice were monitored continuously for 48 hrs with blood sampled serially for blood glucose and plasma insulin determinations.
  • MEASUREMENTS AND MAIN RESULTS: : In both saline- and glucose-infused mice, lipopolysaccharide administration induced transient hemodynamic instability without significant impact on mortality.
  • However, in glucose-infused mice, lipopolysaccharide induced a large and unexpected increase in circulating insulin without significant alteration in blood glucose.
  • CONCLUSIONS: : Endogenous insulin deficiency in the face of hyperglycemia is associated with mortality in a mouse model of lipopolysaccharide-induced critical illness.
  • [MeSH-minor] Animals. Critical Illness. Disease Models, Animal. Male. Mice. Mice, Inbred BALB C. Prognosis. Survival Rate

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  • [CommentIn] Crit Care Med. 2009 Sep;37(9):2665-7 [19687644.001]
  • (PMID = 19623043.001).
  • [ISSN] 1530-0293
  • [Journal-full-title] Critical care medicine
  • [ISO-abbreviation] Crit. Care Med.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK076562; United States / NIDDK NIH HHS / DK / R01 DK077096
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS661742; NLM/ PMC4326234
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62. Pearson BL, Defensor EB, Blanchard DC, Blanchard RJ: C57BL/6J mice fail to exhibit preference for social novelty in the three-chamber apparatus. Behav Brain Res; 2010 Dec 1;213(2):189-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] C57BL/6J mice fail to exhibit preference for social novelty in the three-chamber apparatus.
  • Laboratory models of neurodevelopmental disorders may be useful in assessing investigation and preference for social partners in mice.
  • One such mouse model, the three-chamber test, is increasingly used as an index of social preference.
  • The first phase measures preference for a social stimulus over an identical chamber without a stimulus mouse.
  • The second phase measures preference for a novel mouse compared to the familiar mouse when the latter is presented in the previously empty chamber.
  • In the first study, male C57BL/6J mice subjects encountered C57BL/6J stimuli and preferred a novel mouse over an empty chamber but failed to show a preference for the novel mouse in Phase 2 when the stimuli presentation was reversed.
  • In an additional study, male C57BL/6J subjects encountered outbred CD-1 mice as stimuli, showing no significant novelty preference in either phase.
  • Specific behavioral indices of investigation were similar to these duration findings with no enhancement of investigation when the novel stimulus mouse was encountered in the chamber in which the initial social stimulus was presented.
  • These data suggest that C57BL/6J mice may show enhanced investigation/preference of novel social stimuli in the three-chamber test only when these stimuli are presented in a relatively novel context.

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  • [Copyright] Copyright (c) 2010 Elsevier B.V. All rights reserved.
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  • (PMID = 20452381.001).
  • [ISSN] 1872-7549
  • [Journal-full-title] Behavioural brain research
  • [ISO-abbreviation] Behav. Brain Res.
  • [Language] ENG
  • [Grant] United States / NIMH NIH HHS / MH / MH081845-02; United States / NIMH NIH HHS / MH / R01 MH081845; United States / NIMH NIH HHS / MH / MH081845-01A2; United States / NIMH NIH HHS / MH / R01 MH081845-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ NIHMS217781; NLM/ PMC2921281
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63. Campbell JC, Szumlinski KK, Kippin TE: Contribution of early environmental stress to alcoholism vulnerability. Alcohol; 2009 Nov;43(7):547-54
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  • Accordingly, we have found that male C57BL/6J mice subject to PNS exhibit higher operant responding and consume more alcohol during alcohol reinforcement as adults.

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  • (PMID = 19913199.001).
  • [ISSN] 1873-6823
  • [Journal-full-title] Alcohol (Fayetteville, N.Y.)
  • [ISO-abbreviation] Alcohol
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / R01 AA016650; United States / NIAAA NIH HHS / AA / U01 AA013641; United States / NIDA NIH HHS / DA / R01 DA024038; United States / NIAAA NIH HHS / AA / AA013641-09; United States / NIAAA NIH HHS / AA / U01 AA016650; United States / NIAAA NIH HHS / AA / U01 AA013641-09
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 104
  • [Other-IDs] NLM/ NIHMS288463; NLM/ PMC3096452
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64. Zanon RG, Cartarozzi LP, Victório SC, Moraes JC, Morari J, Velloso LA, Oliveira AL: Interferon (IFN) beta treatment induces major histocompatibility complex (MHC) class I expression in the spinal cord and enhances axonal growth and motor function recovery following sciatic nerve crush in mice. Neuropathol Appl Neurobiol; 2010 Oct;36(6):515-34

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Interferon (IFN) beta treatment induces major histocompatibility complex (MHC) class I expression in the spinal cord and enhances axonal growth and motor function recovery following sciatic nerve crush in mice.
  • METHODS: C57BL/6J mice were subjected to unilateral sciatic nerve crush and treatment with IFN beta.
  • [MeSH-minor] Animals. Axons / drug effects. Axons / metabolism. Axons / ultrastructure. Blotting, Western. Female. Gene Expression / drug effects. Immunohistochemistry. In Situ Hybridization. Mice. Mice, Inbred C57BL. Microscopy, Electron, Transmission. Nerve Crush. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction. Sciatic Nerve / drug effects. Sciatic Nerve / injuries. Sciatic Nerve / ultrastructure

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  • [Copyright] © 2010 The Authors. Neuropathology and Applied Neurobiology © 2010 British Neuropathological Society.
  • (PMID = 20831746.001).
  • [ISSN] 1365-2990
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Histocompatibility Antigens Class I; 0 / Immunologic Factors; 0 / RNA, Messenger; 77238-31-4 / Interferon-beta
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65. Sasaki R, Matsumoto A, Itoh K, Kawabe T, Ota Y, Yamada K, Maruta T, Soejima T, Sugimura K: Target cells of apoptosis in the adult murine dentate gyrus and O4 immunoreactivity after ionizing radiation. Neurosci Lett; 2000 Jan 21;279(1):57-60
The Lens. Cited by Patents in .

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  • [Title] Target cells of apoptosis in the adult murine dentate gyrus and O4 immunoreactivity after ionizing radiation.
  • The occurrence of radiation-induced apoptosis and the determination of target cells were investigated by using the TdT-mediated dUTP-biotin nick end labeling assay and immunohistochemical analyses.
  • C57BL/6J adult female mice were subjected to single dose irradiation of 10 Gy.
  • The target cells of radiation-induced apoptosis are the subgranular progenitor cells and the oligodendrocytes in the hilus.
  • [MeSH-minor] Animals. Immunohistochemistry. Male. Mice. Mice, Inbred C57BL. Oligodendroglia / metabolism. Oligodendroglia / radiation effects. Radiation, Ionizing. Stem Cells / metabolism. Stem Cells / radiation effects

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  • (PMID = 10670787.001).
  • [ISSN] 0304-3940
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] IRELAND
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / oligodendrocyte O antigen, mouse
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66. Ozment TR, Ha T, Breuel KF, Ford TR, Ferguson DA, Kalbfleisch J, Schweitzer JB, Kelley JL, Li C, Williams DL: Scavenger receptor class a plays a central role in mediating mortality and the development of the pro-inflammatory phenotype in polymicrobial sepsis. PLoS Pathog; 2012;8(10):e1002967
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  • SRA deficient (SRA(-/-)) and C57BL/6JB/6J (WT) male mice were subjected to cecal ligation and puncture (CLP) to induce polymicrobial sepsis.
  • Long-term survival was significantly increased in SRA(-/-) septic mice (53.6% vs. 3.6%, p < 0.05) when compared to WT mice.
  • NFκB activity was 45.5% lower in the lungs of SRA(-/-) septic mice versus WT septic mice (p < 0.05).
  • Serum levels of interleukin (IL)-5, IL-6, IL-10 and monocyte chemoattractant protein -1 were significantly lower in septic SRA(-/-) mice when compared to septic WT mice (p < 0.05).
  • We found that SRA immuno-precipitated with TLR4, but not TLR2, in the lungs of WT septic mice.
  • We also found that septic SRA(-/-) mice had lower bacterial burdens than WT septic mice.

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  • (PMID = 23071440.001).
  • [ISSN] 1553-7374
  • [Journal-full-title] PLoS pathogens
  • [ISO-abbreviation] PLoS Pathog.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM053522; United States / NIGMS NIH HHS / GM / GM083016; United States / NIGMS NIH HHS / GM / GM53552; United States / NHLBI NIH HHS / HL / HL071837
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chemokines; 0 / Cytokines; 0 / NF-kappa B; 0 / Scavenger Receptors, Class A; 0 / Tlr2 protein, mouse; 0 / Tlr4 protein, mouse; 0 / Toll-Like Receptor 2; 0 / Toll-Like Receptor 4; EC 1.11.1.7 / Peroxidase
  • [Other-IDs] NLM/ PMC3469655
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67. Qian Y, Huang M, Guan T, Chen L, Cao L, Han XJ, Huang L, Tang X, Li Y, Sun H: Maslinic acid promotes synaptogenesis and axon growth via Akt/GSK-3β activation in cerebral ischemia model. Eur J Pharmacol; 2015 Oct 5;764:298-305
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this study, we investigated the potential effects of maslinic acid on synaptogenesis and axonal regeneration, as well as the possible signal pathway involved in a cerebral ischemia mouse model.
  • Adult male C57BL/6J mice were subjected to 1h of cerebral ischemia by middle cerebral artery occlusion (MCAO).
  • In addition, maslinic acid treatment was shown to enhance Akt activity and promote GSK-3β phorsphorylation in stoke mice.
  • [MeSH-minor] Animals. Cells, Cultured. Cerebral Cortex / cytology. Cerebral Cortex / drug effects. Cerebral Cortex / metabolism. Disease Models, Animal. Male. Mice, Inbred C57BL. Neurons / drug effects. Neurons / metabolism. Synaptophysin / metabolism

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  • [Copyright] Copyright © 2015 Elsevier B.V. All rights reserved.
  • (PMID = 26172083.001).
  • [ISSN] 1879-0712
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Neuroprotective Agents; 0 / Synaptophysin; 0 / Syp protein, mouse; 0 / Triterpenes; 4373-41-5 / maslinic acid; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / glycogen synthase kinase 3 beta; EC 2.7.11.26 / Glycogen Synthase Kinase 3
  • [Keywords] NOTNLM ; Akt / Axon / Cerebral ischemia / GSK-3β / Maslinic acid / synaptophysin
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68. Najean Y, Chedeville A, Eberlin A, Balitrand N: A study of the efficacy of 5 alpha- and 5 beta-androstanes in chronic experimental aplastic anemia in mice. Nouv Rev Fr Hematol; 1984;26(6):391-6
MedlinePlus Health Information. consumer health - Stem Cells.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A study of the efficacy of 5 alpha- and 5 beta-androstanes in chronic experimental aplastic anemia in mice.
  • The efficacy of in vivo administration of a 5 alpha-androstane and two 5 beta-androstanes (3 alpha and 3 beta) on CFU/GM and CFU/E mouse bone marrow stem cells was compared.
  • The subjects were two groups of Swiss Webster mice: one normal group and one group in whom chronic aplastic anemia was induced by irradiation followed by mesenteric node lymphocyte grafting from C57/Bl donor mice.
  • In aplastic mice, 5 alpha and 5 beta-androstanes had the same efficacy on CFU/E but 5 beta-androstanes were more efficient on the granulopoietic committed stem cells.
  • The efficacy of the association of the two compounds in aplastic mice was not superior to that of each drug alone, which can be explained by the depletion of the stem cell compartment induced by the stimulating effect of the first androgen.
  • [MeSH-minor] Animals. Bone Marrow Cells. Female. Mice

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  • (PMID = 6527944.001).
  • [Journal-full-title] Nouvelle revue française d'hématologie
  • [ISO-abbreviation] Nouv Rev Fr Hematol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] GERMANY, WEST
  • [Chemical-registry-number] 97CGB1M48I / Etiocholanolone; C24W7J5D5R / Androsterone; P7W01638W6 / Norethandrolone
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69. Stubbe T, Ebner F, Richter D, Engel O, Klehmet J, Royl G, Meisel A, Nitsch R, Meisel C, Brandt C: Regulatory T cells accumulate and proliferate in the ischemic hemisphere for up to 30 days after MCAO. J Cereb Blood Flow Metab; 2013 Jan;33(1):37-47

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • C57BL/6J and Foxp3(EGFP) transgenic mice were subjected to 30 minutes MCAO.
  • The transfer of naive CD4(+) cells depleted of Foxp3(+) Tregs into RAG1(-/-) mice 1 day before MCAO did not lead to a de novo generation of Tregs 14 days after surgery.
  • [MeSH-minor] Animals. Antigen-Presenting Cells / immunology. CD4-Positive T-Lymphocytes / immunology. Flow Cytometry. Forkhead Transcription Factors / genetics. Forkhead Transcription Factors / immunology. Genes, Reporter. Homeodomain Proteins / genetics. Homeodomain Proteins / immunology. Immunohistochemistry. Interleukin-2 Receptor alpha Subunit / immunology. Lymphocyte Activation / immunology. Lymphocyte Count. Mice. Mice, Inbred C57BL. Mice, Transgenic. Time Factors

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  • [ErratumIn] J Cereb Blood Flow Metab. 2013 Jan;33(1):159. Randolf Engel, Odilo [corrected to Engel, Odilo]
  • (PMID = 22968321.001).
  • [ISSN] 1559-7016
  • [Journal-full-title] Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • [ISO-abbreviation] J. Cereb. Blood Flow Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Forkhead Transcription Factors; 0 / Foxp3 protein, mouse; 0 / Homeodomain Proteins; 0 / Il2ra protein, mouse; 0 / Interleukin-2 Receptor alpha Subunit; 128559-51-3 / RAG-1 protein
  • [Other-IDs] NLM/ PMC3597367
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70. Zhang Q, Lan Y, He XF, Luo CM, Wang QM, Liang FY, Xu GQ, Pei Z: Allopurinol protects against ischemic insults in a mouse model of cortical microinfarction. Brain Res; 2015 Oct 5;1622:361-7
Hazardous Substances Data Bank. Allopurinol .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Allopurinol protects against ischemic insults in a mouse model of cortical microinfarction.
  • C57BL/6J mice were subjected to a permanent single penetrating arteriole occlusion induced by two-photon laser irradiation.
  • [MeSH-minor] Animals. Arterioles. Astrocytes / drug effects. Astrocytes / pathology. Astrocytes / physiology. Cell Proliferation / drug effects. Cell Proliferation / physiology. Disease Models, Animal. Enzyme Inhibitors / pharmacology. Fluorescent Antibody Technique. Lasers. Male. Mice, Inbred C57BL. Microglia / drug effects. Microglia / pathology. Microglia / physiology. Neurons / drug effects. Neurons / pathology. Neurons / physiology. Xanthine Oxidase / antagonists & inhibitors. Xanthine Oxidase / metabolism

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  • [Copyright] Copyright © 2015 Elsevier B.V. All rights reserved.
  • (PMID = 26187758.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Neuroprotective Agents; 63CZ7GJN5I / Allopurinol; EC 1.17.3.2 / Xanthine Oxidase
  • [Keywords] NOTNLM ; Allopurinol / Inflammation / Microinfarcts / Oxidative Stress / Two-photon laser-scanning microscope
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71. Artinger K, Kirsch AH, Aringer I, Schabhüttl C, Rosenkranz AR, Eller P, Rho E, Eller K: The Spleen Plays No Role in Nephrotoxic Serum Nephritis, but Constitutes a Place of Compensatory Haematopoiesis. PLoS One; 2015;10(8):e0135087

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: In order to accelerate the disease, animals were subjected to NTS by preimmunizing male C57BL/6J mice with rabbit IgG three days before injecting the rabbit anti-glomerular basement antiserum, or were immunized only.
  • Splenectomized mice were found to develop albuminuria and renal histological changes comparable to sham-operated controls.
  • Nevertheless, anaemia was aggravated in mice after splenectomy.
  • During the course of NTS, we detected CD41+ megakaryocytes and Ter119+ erythroid precursor cells in the spleen of mice with NTS and of immunized mice.
  • [MeSH-minor] Albuminuria / etiology. Albuminuria / genetics. Albuminuria / immunology. Albuminuria / pathology. Anemia / etiology. Anemia / genetics. Anemia / immunology. Anemia / pathology. Animals. Blood Group Antigens / genetics. Blood Group Antigens / immunology. Bone Marrow / immunology. Bone Marrow / pathology. Chemokine CXCL12 / genetics. Chemokine CXCL12 / immunology. Gene Expression. Immune Sera / adverse effects. Immunization. Immunoglobulin G / adverse effects. Interferon-gamma / genetics. Interferon-gamma / immunology. Kidney Glomerulus / immunology. Kidney Glomerulus / pathology. Male. Megakaryocytes / immunology. Megakaryocytes / pathology. Mice. Mice, Inbred C57BL. Rabbits. Receptors, CXCR4 / genetics. Receptors, CXCR4 / immunology

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  • (PMID = 26247770.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Grant] Austria / Austrian Science Fund FWF / / P 27537
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Group Antigens; 0 / CXCR4 protein, mouse; 0 / Chemokine CXCL12; 0 / Cxcl12 protein, mouse; 0 / Immune Sera; 0 / Immunoglobulin G; 0 / Receptors, CXCR4; 0 / TER-119 antigen, mouse; 82115-62-6 / Interferon-gamma
  • [Other-IDs] NLM/ PMC4527588
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72. Messiha FS: Ethanol and simulated high altitude. A study of three mouse strains. Arch Toxicol; 1982 May;50(1):77-83
Hazardous Substances Data Bank. ACETALDEHYDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ethanol and simulated high altitude. A study of three mouse strains.
  • The effect of short-term exposure of three mouse-strains to simulated high altitude (SHA) of approximately 6,000 m was studied.
  • Subjecting C57BL/6J, DBA/2J or albino mouse strains to SHA for 39 days, occurring on alternating days, increased liver weight in the albino mouse compared to controls.
  • The C57BL strain showed increased growth during SHA compared to other mouse strains.
  • Morbidity score was greater in the albino mouse than in DBA mouse with no death occurring in C57BL mice exposed to SHA.
  • Hepatic alcohol dehydrogenase was induced and mitochondrial aldehyde dehydrogenase was inhibited from corresponding controls subsequent SHA exposure by the C57BL and by the DBA mouse strain, respectively.
  • The onset of ethanol-mediated narcosis was decreased from controls subsequent 21 days of SHA exposure by the DBA and by the albino mouse strain.
  • The central depressant action of ethanol, as measured by the duration of ethanol-narcosis, was decreased in the C57BL mice exposed to SHA for 8, 21, or 35 days compared to controls.
  • No apparent changes occurred in duration of ethanol-narcosis in the other mouse strains.
  • [MeSH-minor] Acetaldehyde / metabolism. Alcoholic Intoxication. Animals. Behavior, Animal / drug effects. Humans. Liver / metabolism. Male. Mice. Mice, Inbred C57BL. Mice, Inbred DBA. Mice, Inbred Strains. Species Specificity

  • Hazardous Substances Data Bank. ETHANOL .
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  • (PMID = 7202351.001).
  • [ISSN] 0340-5761
  • [Journal-full-title] Archives of toxicology
  • [ISO-abbreviation] Arch. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 3K9958V90M / Ethanol; GO1N1ZPR3B / Acetaldehyde
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73. Baunack E, Falk U, Gärtner K: Monozygotic vs. dizygotic twin behavior in artificial mouse twins. Genetics; 1984 Mar;106(3):463-77
Genetic Alliance. consumer health - Dizygotic twins.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Monozygotic vs. dizygotic twin behavior in artificial mouse twins.
  • Adult inbred mice of an isogenic strain (AKR/NHan or C57BL/6J Han) differ in social (sexual and agonistic), emotional and psychomotoric behavior, depending on the kind of manipulation to which they were subjected at an early ontogenetic stage.
  • [MeSH-minor] Animals. Emotions. Female. Humans. Mice. Mice, Inbred Strains. Models, Genetic. Motor Activity. Pregnancy. Sexual Behavior, Animal. Social Behavior

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  • (PMID = 6538528.001).
  • [ISSN] 0016-6731
  • [Journal-full-title] Genetics
  • [ISO-abbreviation] Genetics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] UNITED STATES
  • [Other-IDs] NLM/ PMC1224250
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74. Flanigan TJ, Cook MN: Effects of an early handling-like procedure and individual housing on anxiety-like behavior in adult C57BL/6J and DBA/2J mice. PLoS One; 2011;6(4):e19058
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of an early handling-like procedure and individual housing on anxiety-like behavior in adult C57BL/6J and DBA/2J mice.
  • Evidence suggests that postnatal days (PND) 15-21 are a time of particular susceptibility to environmental influences on anxiety-like behavior in mice.
  • To examine this, we subjected C57BL/6J and DBA/2J mice to an early handling-like procedure.
  • Additionally, we observed a trend of reduced anxiety-like behavior in C57BL/6J, but not DBA/2J mice that underwent the handling-like procedure.
  • [MeSH-minor] Animals. Female. Male. Maze Learning. Mice. Mice, Inbred C57BL. Mice, Inbred DBA

  • MedlinePlus Health Information. consumer health - Anxiety.
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  • (PMID = 21533042.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3080884
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75. Manzer R, Pappa A, Estey T, Sladek N, Carpenter JF, Vasiliou V: Ultraviolet radiation decreases expression and induces aggregation of corneal ALDH3A1. Chem Biol Interact; 2003 Feb 1;143-144:45-53
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Substantial reduction in corneal ALDH3A1 enzymatic activity associated with eye pathology was previously reported in C57BL/6J mice subjected to ultraviolet radiation (UVR).
  • Adult C57BL/6J mice were subjected to UVR exposure (302 nm peak wavelength) for various periods of time, and corneal ALDH3A1 mRNA and protein levels were monitored by Northern and Western blot analysis, respectively.
  • Mice exposed to 0.2 J/cm(2) UVB radiation demonstrated an extensive decrease, approximately 80%, in mRNA and protein levels, as well as enzymatic activity of corneal ALDH3A1.
  • Significant reductions in corneal ALDH3A1 enzymatic activity were detected in mice 96 h after exposure to 0.05 and 0.1 J/cm(2) UVB radiation; no significant changes were observed in mRNA and protein levels.
  • [MeSH-minor] Animals. Blotting, Western. DNA, Complementary. Humans. Male. Mice. Mice, Inbred C57BL. Recombinant Proteins / genetics. Recombinant Proteins / metabolism. Recombinant Proteins / radiation effects

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  • (PMID = 12604188.001).
  • [ISSN] 0009-2797
  • [Journal-full-title] Chemico-biological interactions
  • [ISO-abbreviation] Chem. Biol. Interact.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / 5T32 GM08732; United States / NEI NIH HHS / EY / R29 EY11490
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Recombinant Proteins; EC 1.2.1.3 / Aldehyde Dehydrogenase; EC 1.2.1.3 / Aldh3a1protein, mouse
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76. Li PC, Jiao Y, Ding J, Chen YC, Cui Y, Qian C, Yang XY, Ju SH, Yao HH, Teng GJ: Cystamine improves functional recovery via axon remodeling and neuroprotection after stroke in mice. CNS Neurosci Ther; 2015 Mar;21(3):231-40
MedlinePlus Health Information. consumer health - Stroke.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystamine improves functional recovery via axon remodeling and neuroprotection after stroke in mice.
  • METHODS: Adult male C57BL/6J mice were subjected to photothrombotic model of focal stroke or sham operation.
  • [MeSH-minor] Animals. Azepines / pharmacology. Benzamides / pharmacology. Brain / drug effects. Brain / pathology. Brain / physiopathology. Cell Survival / drug effects. Cell Survival / physiology. Central Nervous System Agents / pharmacology. Disease Models, Animal. Male. Mice, Inbred C57BL. Neural Stem Cells / drug effects. Neural Stem Cells / pathology. Neural Stem Cells / physiology. Neurogenesis / drug effects. Neurogenesis / physiology. Neuronal Plasticity / drug effects. Neuronal Plasticity / physiology. Phosphorylation. Random Allocation. Receptor, trkB / antagonists & inhibitors. Receptor, trkB / metabolism

  • MedlinePlus Health Information. consumer health - Ischemic Stroke.
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  • [Copyright] © 2014 John Wiley & Sons Ltd.
  • (PMID = 25430473.001).
  • [ISSN] 1755-5949
  • [Journal-full-title] CNS neuroscience & therapeutics
  • [ISO-abbreviation] CNS Neurosci Ther
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ANA 12 compound; 0 / Azepines; 0 / Benzamides; 0 / Central Nervous System Agents; 0 / Neuroprotective Agents; EC 2.7.10.1 / Receptor, trkB; R110LV8L02 / Cystamine
  • [Keywords] NOTNLM ; Axonal remodeling / Cystamine / Neuroprotection / Rehabilitation / Stroke
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77. Stuart PM, Pan F, Plambeck S, Ferguson TA: FasL-Fas interactions regulate neovascularization in the cornea. Invest Ophthalmol Vis Sci; 2003 Jan;44(1):93-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: C57BL/6(B6), FasL (CD95L)-deficient B6-gld, and Fas (CD95)-deficient B6-lpr mice were subjected to the suture model of neovascularization.
  • Corneas were evaluated for neovascularization and representative samples subjected to immunohistochemical analysis for expression of Fas antigen and CD31 (platelet-endothelial cell adhesion molecule [PECAM-1]) on vessels that were present in the tissue.
  • Whereas Fas-deficient B6-lpr corneas displayed significantly less neovascularization than normal B6, B6-lpr mice express Fas on growing vessels.
  • In corneal explant cultures, vessel growth from B6 and lpr mice corneas was inhibited by anti-Fas antibody, confirming functional Fas expression in B6-lpr mice.
  • [MeSH-minor] Animals. Antigens, CD31 / metabolism. Cornea / blood supply. Cornea / metabolism. Fas Ligand Protein. Female. Fluorescent Antibody Technique, Indirect. Ligands. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Microscopy, Confocal

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  • (PMID = 12506060.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY 02687; United States / NEI NIH HHS / EY / EY 12826; United States / NEI NIH HHS / EY / R01 EY 06765; United States / NEI NIH HHS / EY / R01 EY 12707
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD95; 0 / Fas Ligand Protein; 0 / Fasl protein, mouse; 0 / Ligands; 0 / Membrane Glycoproteins
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78. Sun J, Morgan M, Shen RF, Steenbergen C, Murphy E: Preconditioning results in S-nitrosylation of proteins involved in regulation of mitochondrial energetics and calcium transport. Circ Res; 2007 Nov 26;101(11):1155-63
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  • Preceding 20 minutes of no-flow ischemia and reperfusion, hearts from C57BL/6J mice were perfused in the Langendorff mode and subjected to the following conditions:.

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  • (PMID = 17916778.001).
  • [ISSN] 1524-4571
  • [Journal-full-title] Circulation research
  • [ISO-abbreviation] Circ. Res.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL039752; United States / NHLBI NIH HHS / HL / HL-39752; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cardiotonic Agents; 0 / Nitrogen Oxides; 0 / Proteins; SY7Q814VUP / Calcium
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79. Hattori Y, Kitamura A, Nagatsuka K, Ihara M: A novel mouse model of ischemic carotid artery disease. PLoS One; 2014;9(6):e100257

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A novel mouse model of ischemic carotid artery disease.
  • METHODS: Adult C57BL/6J male mice were subjected to ameroid constrictor (AC) placement to gradually narrow the bilateral common carotid arteries.
  • Surviving mice with AC showed continuous reduction of CBF by up to 70% of the baseline level at 28 days.
  • Most of the mice (75%) showed multiple cerebral infarctions in the gray and white matter.
  • Non-surviving mice showed critical CBF reduction below 20-30% of the baseline level before death.
  • CONCLUSION: The application of the AC on the bilateral common carotid arteries in mice could offer a reliable model of severe cerebrovascular insufficiency due to carotid artery occlusive disease and may thus be useful in exploring pharmacological intervention in stroke through monitoring survival rate, infarct formation, and CBF profile.
  • [MeSH-major] Carotid Artery, Common / pathology. Carotid Stenosis / pathology. Cerebral Infarction / pathology. Disease Models, Animal. Ischemia / pathology. Mice, Inbred C57BL
  • [MeSH-minor] Animals. Blood Flow Velocity. Brain / blood supply. Brain / pathology. Brain / physiopathology. Cerebrovascular Circulation. Humans. Male. Mice. Regional Blood Flow. Survival Analysis

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  • (PMID = 24940742.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4062537
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80. Nadler JJ, Moy SS, Dold G, Trang D, Simmons N, Perez A, Young NB, Barbaro RP, Piven J, Magnuson TR, Crawley JN: Automated apparatus for quantitation of social approach behaviors in mice. Genes Brain Behav; 2004 Oct;3(5):303-14
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Automated apparatus for quantitation of social approach behaviors in mice.
  • Mouse models of social dysfunction, designed to investigate the complex genetics of social behaviors, require an objective methodology for scoring social interactions relevant to human disease symptoms.
  • Here we describe an automated, three chambered apparatus designed to monitor social interaction in the mouse.
  • When tested with the automated equipment, juvenile male C57BL/6J mice spent more time in a chamber containing a stranger mouse than in an empty chamber (sociability), similar to results obtained by the observer scored method.
  • Sniffing directed at the wire cage containing the stranger mouse correlated significantly with time spent in that chamber, indicating that duration in a chamber represents true social approach behavior.
  • Application of these methods to C57BL/6J, DBA/2J and FVB/NJ adult males revealed that all three strains displayed tendencies for sociability and preference for social novelty.
  • To evaluate the importance of the strain of the stranger mouse on sociability and preference for social novelty, C57BL/6J subject mice were tested either with A/J strangers or with C57BL/6J strangers.
  • The automated equipment provides an accurate and objective approach to measuring social tendencies in mice.
  • Its use may allow higher-throughput scoring of mouse social behaviors in mouse models of social dysfunction.
  • [MeSH-minor] Animals. Equipment Design. Male. Mice. Mice, Inbred C57BL. Mice, Inbred Strains. Species Specificity

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  • (PMID = 15344923.001).
  • [ISSN] 1601-1848
  • [Journal-full-title] Genes, brain, and behavior
  • [ISO-abbreviation] Genes Brain Behav.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / P30 HD03110; United States / NICHD NIH HHS / HD / T32-HD40127; United States / NIMH NIH HHS / MH / U54 MH66418
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
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81. Judex S, Garman R, Squire M, Busa B, Donahue LR, Rubin C: Genetically linked site-specificity of disuse osteoporosis. J Bone Miner Res; 2004 Apr;19(4):607-13
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  • The genetic influence on bone loss in response to mechanical unloading was investigated within diaphyseal and distal femoral regions in three genetically distinct strains of mice.
  • One mouse strain failed to lose bone after removal of function, whereas osteopenia was evident in multiple regions of the remaining two strains but in different areas of the bone.
  • Here, the extent to which genetic variations influence regional bone loss caused by disuse was studied in the femora of adult female mice from three inbred strains.
  • MATERIALS AND METHODS: Adult C57BL/6J (B6), C3H/HeJ (C3H), and BALB/cByJ (BALB) mice were subjected to 15-21 days of disuse, achieved by hindlimb suspension, and six distinct anatomical regions of the femur were analyzed by high-resolution microCT.
  • RESULTS AND CONCLUSIONS: In B6 mice, the amount of disuse stimulated bone loss was relatively uniform across all regions, with 20% loss of trabecular bone and 10% loss of cortical bone.
  • The degree of bone loss in BALB mice varied greatly, ranging from 59% in the metaphysis to 3% in the proximal diaphysis.
  • In direct contrast with BALB and B6, disuse failed to produce significant losses of bone in any of the analyzed regions of the C3H mice.
  • [MeSH-minor] Animals. Female. Immobilization. Mice. Mice, Inbred Strains

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  • (PMID = 15005848.001).
  • [ISSN] 0884-0431
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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82. Guo X, Li H, Xu H, Halim V, Zhang W, Wang H, Ong KT, Woo SL, Walzem RL, Mashek DG, Dong H, Lu F, Wei L, Huo Y, Wu C: Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice. PLoS One; 2012;7(6):e39286
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  • [Title] Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice.
  • Male wild-type C57BL/6J mice were supplemented with palmitoleate and subjected to the assays to analyze hepatic steatosis and liver inflammatory response.
  • Additionally, mouse primary hepatocytes were treated with palmitoleate and used to analyze fat deposition, the inflammatory response, and sterol regulatory element-binding protein 1c (SREBP1c) activation.
  • Locally, hepatic fat deposition and SREBP1c and FAS expression were significantly increased in palmitoleate-supplemented mice.
  • In addition, palmitoleate supplementation reduced the numbers of macrophages/Kupffer cells in livers of the treated mice.
  • These results were recapitulated in primary mouse hepatocytes.

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  • (PMID = 22768070.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R21 HL108922; United States / NHLBI NIH HHS / HL / HL78679; United States / NHLBI NIH HHS / HL / R01 HL080569; United States / NHLBI NIH HHS / HL / R01 HL078679; United States / NHLBI NIH HHS / HL / R01 HL095556; United States / NHLBI NIH HHS / HL / HL080569
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fatty Acids, Monounsaturated; 0 / Sterol Regulatory Element Binding Protein 1; 209B6YPZ4I / palmitoleic acid; EC 2.3.1.85 / Fatty Acid Synthases
  • [Other-IDs] NLM/ PMC3387145
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83. Shearer J, Ross KD, Hughey CC, Johnsen VL, Hittel DS, Severson DL: Exercise training does not correct abnormal cardiac glycogen accumulation in the db/db mouse model of type 2 diabetes. Am J Physiol Endocrinol Metab; 2011 Jul;301(1):E31-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Exercise training does not correct abnormal cardiac glycogen accumulation in the db/db mouse model of type 2 diabetes.
  • Control (db(+)) and genetically diabetic (db/db) C57BL/KsJ-lepr(db)/lepr(db) mice were subjected to sedentary or treadmill exercise regimens.
  • Phosphorylation (Ser(640)) of glycogen synthase, an indicator of enzymatic fractional activity, was greater in db/db mice subjected to sedentary and exercise regimens.
  • [MeSH-minor] Animals. Body Weight / physiology. Exercise Therapy. Glycogen Storage Disease Type IIb / genetics. Glycogen Storage Disease Type IIb / metabolism. Glycogen Storage Disease Type IIb / therapy. Mice. Mice, Inbred C57BL. Mice, Transgenic. Receptors, Leptin / genetics

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  • (PMID = 21386062.001).
  • [ISSN] 1522-1555
  • [Journal-full-title] American journal of physiology. Endocrinology and metabolism
  • [ISO-abbreviation] Am. J. Physiol. Endocrinol. Metab.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / / MOP 79397
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Leptin; 9005-79-2 / Glycogen
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84. Gerbase-DeLima M, Liu RK, Cheney KE, Mickey R, Walford RL: Immune function and survival in a long-lived mouse strain subjected to undernutrition. Gerontologia; 1975;21(4):184-202
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  • [Title] Immune function and survival in a long-lived mouse strain subjected to undernutrition.
  • Functional immune changes were monitored in populations of the long-lived C57BL/6J strain of mice which were subjected to dietary restriction from time of weaning or subjected to such restriction both before and after weaning, along with the appropriate control populations.
  • Early in life, restricted mice appear immunosuppressed, as judged by all these parameters.
  • Other responses tended to reverse from the earlier pattern; by mid-life restricted mice responded better than controls.
  • Mice on such regimes display anatomic and certain immune functional changes which suggest that the immune system may mature less rapidly and stay "younger" longer than in the controls.
  • [MeSH-minor] Animals. Body Weight. Concanavalin A / pharmacology. Diet. Dietary Proteins. Female. Hemolytic Plaque Technique. Lectins / pharmacology. Life Expectancy. Lipopolysaccharides / pharmacology. Male. Mice. Mice, Inbred A. Mice, Inbred C57BL. Mitogens. Nutritional Requirements. Organ Size. Skin Transplantation. Spleen / cytology. Spleen / immunology. T-Lymphocytes / immunology. Thymectomy. Transplantation, Homologous

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  • (PMID = 1102395.001).
  • [ISSN] 0016-898X
  • [Journal-full-title] Gerontologia
  • [ISO-abbreviation] Gerontologia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] SWITZERLAND
  • [Chemical-registry-number] 0 / Dietary Proteins; 0 / Lectins; 0 / Lipopolysaccharides; 0 / Mitogens; 11028-71-0 / Concanavalin A
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85. Olivi M, Barbieri G, Paoletti I: [Repeatibility of an experiment: high incidence of subcutaneous sarcomas in mice of the C57BL-Cb/Se substrain subjected to oil injections of estradiol benzoate]. Lav Ist Anat Istol Patol Univ Studi Perugia; 1965;25(2):97-100
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  • [Title] [Repeatibility of an experiment: high incidence of subcutaneous sarcomas in mice of the C57BL-Cb/Se substrain subjected to oil injections of estradiol benzoate].
  • [Transliterated title] Ripetibilità di un esperimento: ala incidenza di sarcomi sottocutanei nei topi del C57BL-Cb/Se substrain sottoposti a iniezioni oleose di benzoato di estradiolo.
  • [MeSH-minor] Animals. Carcinogens. Injections, Subcutaneous. Mice

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  • (PMID = 5833503.001).
  • [ISSN] 0041-8943
  • [Journal-full-title] Lavori dell'Istituto di anatomia e istologia patologica, Università degli studi di Perugia
  • [ISO-abbreviation] Lav Ist Anat Istol Patol Univ Studi Perugia
  • [Language] ita
  • [Publication-type] Journal Article
  • [Publication-country] ITALY
  • [Chemical-registry-number] 0 / Carcinogens; 4TI98Z838E / Estradiol
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86. Bowler RP, Sheng H, Enghild JJ, Pearlstein RD, Warner DS, Crapo JD: A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. Free Radic Biol Med; 2002 Oct 15;33(8):1141-52
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  • We hypothesized that a catalytic antioxidant AEOL 10150 [manganese (III) meso-tetrakis (di-N-ethylimidazole) porphyrin] would attenuate changes in brain gene expression in a mouse model of transient middle cerebral artery occlusion (MCAO).
  • C57BL/6J mice were subjected to either sham surgery or 60 min of right MCAO.
  • [MeSH-minor] Animals. Apoptosis / genetics. Catalysis. Chemokine CXCL2. Chemokines / biosynthesis. Chemokines / genetics. Disease Models, Animal. Drug Evaluation, Preclinical. Gene Expression Profiling. Growth Substances / biosynthesis. Growth Substances / genetics. Heat-Shock Proteins / biosynthesis. Heat-Shock Proteins / genetics. Infusions, Intravenous. Interleukin-6 / biosynthesis. Interleukin-6 / genetics. Male. Mice. Mice, Inbred C57BL. Molecular Structure. Nerve Tissue Proteins / biosynthesis. Nerve Tissue Proteins / genetics. Oligonucleotide Array Sequence Analysis. Oxidation-Reduction. Oxidative Stress. RNA, Messenger / biosynthesis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 12374626.001).
  • [ISSN] 0891-5849
  • [Journal-full-title] Free radical biology & medicine
  • [ISO-abbreviation] Free Radic. Biol. Med.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL-04407; United States / NHLBI NIH HHS / HL / HL-31992; United States / NHLBI NIH HHS / HL / HL-42444; United States / NINDS NIH HHS / NS / NS38944
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Chemokine CXCL2; 0 / Chemokines; 0 / Cxcl2 protein, mouse; 0 / Growth Substances; 0 / Heat-Shock Proteins; 0 / Interleukin-6; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger
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87. Rogers J, Shoemaker WJ, Morgan DG, Finch CE: Senescent change in tissue weight and immunoreactive beta-endorphin, enkephalin, and vasopressin in eight regions of C57BL/6J mouse brain and pituitary. Neurobiol Aging; 1985;6(1):1-9
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  • [Title] Senescent change in tissue weight and immunoreactive beta-endorphin, enkephalin, and vasopressin in eight regions of C57BL/6J mouse brain and pituitary.
  • Groups of naive male C57BL/6J mice, 8-12 months old and 28-32 months old, served as subjects.
  • Old mice exhibited significant decline in anterior pituitary and hippocampus weight.
  • Assays were replicated in later experiments using additional subjects, for total Ns of up to 54 mice.
  • [MeSH-minor] Animals. Brain Stem / analysis. Cerebral Cortex / analysis. Corpus Striatum / analysis. Hippocampus / analysis. Hypothalamus / analysis. Male. Mice. Mice, Inbred C57BL. Mice, Inbred Strains. Organ Size. beta-Endorphin

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  • (PMID = 3158833.001).
  • [ISSN] 0197-4580
  • [Journal-full-title] Neurobiology of aging
  • [ISO-abbreviation] Neurobiol. Aging
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / AG00117; United States / NIA NIH HHS / AG / AG00446; United States / NIA NIH HHS / AG / AG03732
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Endorphins; 0 / Enkephalins; 11000-17-2 / Vasopressins; 60617-12-1 / beta-Endorphin
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88. Krawczyk-Kuliś M, Hołowiecki J, Stella-Hołowiecka B, Rudzka E, Jarczok K: Studies on receptor for mouse erythrocytes in lymphocytes of patients with malignant lymphoma. Arch Immunol Ther Exp (Warsz); 1979;27(4):511-6
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  • [Title] Studies on receptor for mouse erythrocytes in lymphocytes of patients with malignant lymphoma.
  • In a group of 30 healthy subjects and 27 patients with the diagnosis of non-Hodgkins, lymphoma, the rosette test was performed with erythrocytes of mice of the C57 BL strain according to the method of Stathopoulos and Elliott.
  • In healthy subjects, 12.6 +/- 6.9% of lymphocytes possessed receptors for mouse erythrocytes.
  • It was concluded that the rosette test with erythrocytes from mice of the C57 BL strain detects low differentiated forms of B lymphocytes and could be useful in the diagnosis of chronic lymphocytic leukemia and differentiation from lymphosarcoma.
  • [MeSH-minor] Animals. Diagnosis, Differential. Humans. Leukemia, Lymphoid / diagnosis. Lymphoma, Non-Hodgkin / diagnosis. Mice. Mice, Inbred C57BL / immunology. Rosette Formation

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  • (PMID = 583207.001).
  • [ISSN] 0004-069X
  • [Journal-full-title] Archivum immunologiae et therapiae experimentalis
  • [ISO-abbreviation] Arch. Immunol. Ther. Exp. (Warsz.)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] POLAND
  • [Chemical-registry-number] 0 / Receptors, Immunologic
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89. Burman O, Buccarello L, Redaelli V, Cervo L: The effect of two different Individually Ventilated Cage systems on anxiety-related behaviour and welfare in two strains of laboratory mouse. Physiol Behav; 2014 Jan 30;124:92-9
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  • [Title] The effect of two different Individually Ventilated Cage systems on anxiety-related behaviour and welfare in two strains of laboratory mouse.
  • This study investigated the impact of two Individually Ventilated Cage (IVC) housing systems on anxiety-related behaviour and welfare indicators in two common strains of laboratory mice.
  • Subjects were juvenile female C57BL/6J and BALB/c mice (N=128) housed in groups of four in two different IVC systems for 7weeks.
  • Mice were assessed twice a week (e.g. bodyweight) or at the end of the study (e.g. anxiety tests).
  • Mice in System Two, regardless of strain, defecated more in the Elevated Plus Maze (EPM), spent less time in the open arms of the EPM, and less time in the central zone of the Open Field (OF).
  • Strain differences in anxiety-like behaviour were seen in the increased defecation by BALB/c mice in the OF and EPM and less time spent in the open arms of the EPM compared to C57BL/6J mice.
  • These results suggest that different IVC housing systems can influence mouse behaviour in different ways, with mice of both strains studied exhibiting more anxiety-related behaviour when housed in System Two (air entry at the 'animal' level at 50 ACH), which could impact upon experimental data.
  • [MeSH-minor] Animals. Body Weight. Corticosterone / analysis. Drinking. Eating. Feces / chemistry. Female. Maze Learning. Mice. Mice, Inbred BALB C. Mice, Inbred C57BL. Species Specificity. Wounds and Injuries / psychology

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  • [Copyright] © 2013. Published by Elsevier Inc. All rights reserved.
  • (PMID = 24184492.001).
  • [ISSN] 1873-507X
  • [Journal-full-title] Physiology & behavior
  • [ISO-abbreviation] Physiol. Behav.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] W980KJ009P / Corticosterone
  • [Keywords] NOTNLM ; Anxiety-related behaviour / IVC systems / Laboratory mice / Rodent housing
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90. Matsuo N, Takao K, Nakanishi K, Yamasaki N, Tanda K, Miyakawa T: Behavioral profiles of three C57BL/6 substrains. Front Behav Neurosci; 2010;4:29
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  • [Title] Behavioral profiles of three C57BL/6 substrains.
  • C57BL/6 inbred strains of mice are widely used in knockout and transgenic research.
  • However, an issue of C57BL/6 substrains that is not always appreciated is that behaviors are known to be strongly influenced by genetic background.
  • To investigate the behavioral characteristics of C57BL/6 substrains, we subjected C57BL/6J, C57BL/6N, and C57BL/6C mice to a behavior test battery.
  • We performed both a regular scale analysis, in which experimental conditions were tightly controlled, and large-scale analysis from large number of behavioral data that we have collected so far through the comprehensive behavioral test battery applied to 700-2,200 mice in total.
  • Our results show a divergence of behavioral performance in C57BL/6 substrains, which suggest that small genetic differences may have a great influence on behavioral phenotypes.

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  • (PMID = 20676234.001).
  • [ISSN] 1662-5153
  • [Journal-full-title] Frontiers in behavioral neuroscience
  • [ISO-abbreviation] Front Behav Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC2912075
  • [Keywords] NOTNLM ; C57BL/6 / behavior / inbred strain / mouse
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91. Terado M, Nomura M, Mineta K, Fujimoto N, Matsumoto T: Expression of Neuropeptide Y gene in mouse testes during testicular development. Asian J Androl; 2006 Jul;8(4):443-9
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  • [Title] Expression of Neuropeptide Y gene in mouse testes during testicular development.
  • METHODS: In the first experiment, C57BL/6J male mice at the ages of 3 days as well as 2, 3, 5 and 8 weeks were used.
  • In the second and third experiments, adult C57BL/6J male mice were subjected to fasting for 48 h and experimental cryptorchidism for 72 h.
  • [MeSH-minor] Animals. Base Sequence. DNA Primers. In Situ Hybridization. Male. Mice. Mice, Inbred C57BL. RNA, Messenger / genetics. RNA, Messenger / metabolism

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  • (PMID = 16763720.001).
  • [ISSN] 1008-682X
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Neuropeptide Y; 0 / RNA, Messenger
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92. Ale MT, Maruyama H, Tamauchi H, Mikkelsen JD, Meyer AS: Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo. Int J Biol Macromol; 2011 Oct 1;49(3):331-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo.
  • Male C57BL/6JJCL mice were subjected to daily i.p. injections over 4 days with either SIG or MTA fucoidan (50mg/kg body wt.).
  • The cytolytic activity of natural killer (NK) cells was enhanced by crude fucoidan in a dose-dependent manner as indicated by (51)Cr labeled YAC-1 target cell release.
  • This study provides substantial indications that crude fucoidan exerts bioactive effects on lung and skin cancer model cells in vitro and induces enhanced natural killer cell activity in mice in vivo.
  • [MeSH-minor] Animals. Apoptosis / drug effects. Carcinoma, Lewis Lung / immunology. Carcinoma, Lewis Lung / pathology. Cell Line, Tumor. Cell Proliferation / drug effects. Cell Survival / drug effects. Complex Mixtures / isolation & purification. Complex Mixtures / pharmacology. Male. Mice. Mice, Inbred C57BL. Skin Neoplasms / immunology. Skin Neoplasms / pathology

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  • [Copyright] Copyright © 2011 Elsevier B.V. All rights reserved.
  • (PMID = 21624396.001).
  • [ISSN] 1879-0003
  • [Journal-full-title] International journal of biological macromolecules
  • [ISO-abbreviation] Int. J. Biol. Macromol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Complex Mixtures; 0 / Polysaccharides; 9072-19-9 / fucoidan
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93. McGinn MD, Henry KR: Acute versus chronic acoustic deprivation: effects on auditory evoked potentials and seizures in mice. Dev Psychobiol; 1975 May;8(3):223-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute versus chronic acoustic deprivation: effects on auditory evoked potentials and seizures in mice.
  • C57BL/6J mice are not typically susceptible to audiogenic seizures, but temporary conductive hearing loss (via earplugging) can induce susceptibility in these subjects.
  • But mice deprived of acoustic input between ages 42-46 days exhibited equally large or even larger AEP amplitudes, while not exhibiting susceptibility to audiogenic seizures.
  • [MeSH-minor] Age Factors. Animals. Auditory Cortex / physiology. Critical Period (Psychology). Hearing Disorders / etiology. Mice. Mice, Inbred C57BL. Noise / adverse effects. Reaction Time. Time Factors

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  • (PMID = 1230340.001).
  • [ISSN] 0012-1630
  • [Journal-full-title] Developmental psychobiology
  • [ISO-abbreviation] Dev Psychobiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
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94. Smith TL, Vickers A: Increases in liver microsomal phosphatidylethanolamine methyltransferase activity(s) in mice after short-term ethanol treatments. Subst Alcohol Actions Misuse; 1984;5(3):131-40
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  • [Title] Increases in liver microsomal phosphatidylethanolamine methyltransferase activity(s) in mice after short-term ethanol treatments.
  • Adult C57/BL mice subjected to short term ethanol liquid diets exhibited significant increases in liver microsomal phosphatidylethanolamine methyltransferase activity(s) as well as changes in microsomal lipid composition.
  • Dietary supplementation with 2% choline reduced liver methyltransferase activities of both control and ethanol treated mice.
  • [MeSH-minor] Alcohol Drinking. Animals. Cholesterol / metabolism. Fatty Acids / metabolism. Humans. Isoenzymes / metabolism. Male. Mice. Mice, Inbred C57BL. Phosphatidyl-N-Methylethanolamine N-Methyltransferase. Phosphatidylcholines / metabolism. Phosphatidylethanolamine N-Methyltransferase. Phosphatidylethanolamines / metabolism. Phospholipids / metabolism

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  • (PMID = 6542256.001).
  • [ISSN] 0191-8877
  • [Journal-full-title] Substance and alcohol actions/misuse
  • [ISO-abbreviation] Subst Alcohol Actions Misuse
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Fatty Acids; 0 / Isoenzymes; 0 / Phosphatidylcholines; 0 / Phosphatidylethanolamines; 0 / Phospholipids; 97C5T2UQ7J / Cholesterol; EC 2.1.1.- / Methyltransferases; EC 2.1.1.17 / Phosphatidylethanolamine N-Methyltransferase; EC 2.1.1.71 / Phosphatidyl-N-Methylethanolamine N-Methyltransferase
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95. Sergievich LA, Karnaukhov AV, Karnaukhova EV, Karnaukhova NA, Smirnov AA, Bogdanenko EV, Zhugotskiĭ AV, Manokhina IA, Karnaukhov VN: [Use of fluorescence microspectral method for studying bone marrow EGFP+ cells transplantation in 5-fluorouracil-treated mice]. Biofizika; 2014 Jul-Aug;59(4):740-8
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  • [Title] [Use of fluorescence microspectral method for studying bone marrow EGFP+ cells transplantation in 5-fluorouracil-treated mice].
  • In this paper the experimental results of bone marrow transplantation from C57BL/6-Tg(ACTB-EGFP)1Osb/J transgenic mice into C57BL/6 mice subjected to 5-fluorouracil treatment are represented.
  • It has been shown that EGFP+ cells engraftment in bone marrow, spleen and thymus of host mice after 5-Fu treatment significantly increased.
  • [MeSH-minor] Animals. Mice. Mice, Transgenic. Spectrometry, Fluorescence

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  • (PMID = 25707242.001).
  • [ISSN] 0006-3029
  • [Journal-full-title] Biofizika
  • [ISO-abbreviation] Biofizika
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; U3P01618RT / Fluorouracil
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96. Li Y, Liu Z, Liu B, Zhao T, Chong W, Wang Y, Alam HB: Citrullinated histone H3: a novel target for the treatment of sepsis. Surgery; 2014 Aug;156(2):229-34
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  • [Title] Citrullinated histone H3: a novel target for the treatment of sepsis.
  • The present study was designed to test whether treatment with HDACI could inhibit cellular Cit H3 production, and inhibition of peptidylarginine deiminase (PAD, an enzyme producing Cit H3) with Cl-amidine (PAD inhibitor) or neutralization of blood Cit H3 with anti-Cit H3 antibody could improve survival in a clinically relevant mouse model of cecal ligation and puncture (CLP)-induced septic shock.
  • In experiment I, HL-60 neutrophilic cells grown on a coverslip were treated with LPS (100 ng/mL) in the presence or absence of SAHA (5 μmol) for 3 hours, and subjected to immunostaining with anti-Cit H3 antibody to assess effect of SAHA on Cit H3 production under a fluorescence microscope.
  • In experiment II, male C57BL/6J mice were subjected to CLP, and 1 hour later randomly divided into 2 groups for intraperitoneal injection as follows:.
  • In experiment III, male C57BL/6J mice were divided into control and treatment groups, and subjected to CLP.
  • In experiment II, all vehicle-injected mice died within 3 days with increased circulating Cit H3 levels, whereas treatment with HDACI or Cl-amidine notably improved long-term survival (P < .01).
  • Neutralization of Cit H3 significantly improves survival in septic mice.
  • Collectively, our findings indicate for the first time that Cit H3 could not only serve as a potential biomarker, but also a novel therapeutic target in sepsis.

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  • [Copyright] Copyright © 2014 Mosby, Inc. All rights reserved.
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  • (PMID = 24957671.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM084127; United States / NIGMS NIH HHS / GM / R01GM084127
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neutralizing; 0 / Biomarkers; 0 / Enzyme Inhibitors; 0 / Histone Deacetylase Inhibitors; 0 / Histones; 0 / Hydroxamic Acids; 0 / N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide; 29VT07BGDA / Citrulline; 58IFB293JI / vorinostat; E524N2IXA3 / Ornithine; EC 3.- / Hydrolases; EC 3.5.3.15 / peptidylarginine deiminase 4, mouse
  • [Other-IDs] NLM/ NIHMS588105; NLM/ PMC4267527
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97. Chiu S, Hsu K, Greenhalgh DG, Cho K: Post-injury stress signals alter epigenetic profile of cytosine methylation in the proviral genome of endogenous retroviruses. Exp Mol Pathol; 2010 Dec;89(3):291-300
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  • Female C57BL/6J mice were subjected to ~18% total body surface area burn.
  • [MeSH-minor] Animals. Base Sequence. DNA Methylation. Female. Liver / physiology. Mice. Mice, Inbred C57BL. Molecular Sequence Data. Polymerase Chain Reaction. Proviruses / genetics. Signal Transduction / genetics

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20609362.001).
  • [ISSN] 1096-0945
  • [Journal-full-title] Experimental and molecular pathology
  • [ISO-abbreviation] Exp. Mol. Pathol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R01GM071360
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 8J337D1HZY / Cytosine
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98. Marotta M, Sarria Y, Ruiz-Roig C, Munell F, Roig-Quilis M: Laser microdissection-based expression analysis of key genes involved in muscle regeneration in mdx mice. Neuromuscul Disord; 2007 Oct;17(9-10):707-18

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laser microdissection-based expression analysis of key genes involved in muscle regeneration in mdx mice.
  • We have used the mdx mice strain (C57BL/10ScSn-mdx) as an experimental subject for the study of reiterative skeletal muscle necrosis-regeneration with basement membrane preservation.
  • [MeSH-minor] Animals. Lasers. Mice. Mice, Inbred C57BL. Mice, Inbred mdx. Microdissection / methods. MyoD Protein. Myogenic Regulatory Factor 5. Myogenin. RNA, Messenger / biosynthesis. Reverse Transcriptase Polymerase Chain Reaction / methods

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  • (PMID = 17611107.001).
  • [ISSN] 0960-8966
  • [Journal-full-title] Neuromuscular disorders : NMD
  • [ISO-abbreviation] Neuromuscul. Disord.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Muscle Proteins; 0 / Myf5 protein, mouse; 0 / MyoD Protein; 0 / MyoD1 myogenic differentiation protein; 0 / Myogenic Regulatory Factor 5; 0 / Myogenin; 0 / RNA, Messenger
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99. Wisnoski N, Chung CS, Chen Y, Huang X, Ayala A: The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis. Shock; 2007 Mar;27(3):251-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To study this, C57BL/6J, C57BL/6-Il6(tm1Kopf) (interleukin [IL] 6 -/-), and C57BL/6-Il10(tm1Cgn) (IL-10 -/-) mice were subjected to cecal ligation and puncture (CLP) or sham operations.
  • The results indicate a marked elevation in CD4+ CD25+ cell levels and their proliferation index after sepsis in background mice.
  • CD4+ CD25- cells from sham and CLP mice proliferated equally.
  • However, coculture of CD4+ CD25- with CD4+ CD25+ cells suppressed their proliferation in both sham and CLP mice.
  • Subsequently, IL-6 -/- and IL-10 -/- mice were used to elucidate the possible mediator(s) regulating the changes seen after sepsis.
  • Although CD4+ CD25+ cells increased after septic insult in both C57BL/6J and IL-6 -/- mice, this was not observed in IL-10 -/- mice.
  • Similarly, in vitro proliferation studies showed that proliferation index increased in CD4+ CD25+ cells from septic C57BL/6J and IL6 -/- mice, but it remained the same in IL-10 -/- mice.

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  • (PMID = 17304105.001).
  • [ISSN] 1073-2322
  • [Journal-full-title] Shock (Augusta, Ga.)
  • [ISO-abbreviation] Shock
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM046354; United States / NIGMS NIH HHS / GM / R01-GM46354
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD4; 0 / Interleukin-2 Receptor alpha Subunit; 130068-27-8 / Interleukin-10
  • [Other-IDs] NLM/ NIHMS10553; NLM/ PMC1805637
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100. Coleman R, Silbermann M, Gershon D, Reznick AZ: Giant mitochondria in the myocardium of aging and endurance-trained mice. Gerontology; 1987;33(1):34-9
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  • [Title] Giant mitochondria in the myocardium of aging and endurance-trained mice.
  • During the course of an ultrastructural study on the apex region of the left ventricular myocardium of experimental female C57BL/6J mice, aged between 6 and 27 months, and that had been subjected to long-term daily enforced endurance running schedules, we encountered some instances of unusual giant mitochondria.
  • These giant mitochondria were most common in the myocardium of mice that had followed endurance training schedules for 10 or 15 months and were not encountered in age-matched nonrunning control mice.
  • [MeSH-minor] Animals. Female. Mice. Mice, Inbred C57BL. Physical Conditioning, Animal. Physical Endurance

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  • (PMID = 3596262.001).
  • [ISSN] 0304-324X
  • [Journal-full-title] Gerontology
  • [ISO-abbreviation] Gerontology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] SWITZERLAND
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